(R)-2-Methyl-5-oxo-tetrahydrofurane-2-carboxylicacid

Base Information

Chemical Name:(R)-2-Methyl-5-oxo-tetrahydrofurane-2-carboxylicacid
CAS No.:21461-86-9
Molecular Formula:C6H8 O4
Molecular Weight:144.127
Hs Code.:2932190090
Mol file:21461-86-9.mol

Synonyms:2-Furancarboxylicacid, tetrahydro-2-methyl-5-oxo-, (R)-; 2-Furoic acid,tetrahydro-2-methyl-5-oxo-, (R)- (8CI)

Suppliers and Price of (R)-2-Methyl-5-oxo-tetrahydrofurane-2-carboxylicacid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of (R)-2-Methyl-5-oxo-tetrahydrofurane-2-carboxylicacid

Chemical Property:

PSA：52.60000
LogP:-0.13500

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-2-Methyl-5-oxo-tetrahydrofurane-2-carboxylicacid

There total 3 articles about (R)-2-Methyl-5-oxo-tetrahydrofurane-2-carboxylicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 87-91-2
diethyl (2R,3R)-tartrate

: 80-71-7
2-hydroxy-3-methylcyclopent-2-en-1-one

: 21461-89-2
(S)-(-)-tetrahydro-2-methyl-5-oxo-2-furancarboxylic acid

: 21461-86-9
(5R)-γ-valerolactone γ-carboxylic acid

: 2,5-dihydroxy-5-methylcyclopent-2-en-1-one

: (S)-2-Hydroxy-2-methyl-pentanedioic acid 1-((1R,2R)-1,2-bis-ethoxycarbonyl-2-hydroxy-ethyl) ester

Guidance literature:: diethyl (2R,3R)-tartrate; 2-hydroxy-3-methylcyclopent-2-en-1-one; With titanium(IV) isopropylate; 4 A molecular sieve; In dichloromethane; at -20 ℃; for 0.5h;

With tert.-butylhydroperoxide; In decane; dichloromethane; at -20 ℃; for 68h; Further byproducts given;
DOI:10.1016/S0957-4166(03)00309-4

Reference yield:

: 80-71-7
2-hydroxy-3-methylcyclopent-2-en-1-one

: 21461-89-2
(S)-(-)-tetrahydro-2-methyl-5-oxo-2-furancarboxylic acid

: 123-76-2
levulinic acid

: 21461-86-9
(5R)-γ-valerolactone γ-carboxylic acid

Guidance literature:: 2-hydroxy-3-methylcyclopent-2-en-1-one; With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate; In decane; dichloromethane; at -20 ℃; for 68h;

With sodium hydroxide; sodium chloride; at 20 ℃; for 2h;

With hydrogenchloride; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.tetlet.2006.04.013

Reference yield:

: 80-71-7
2-hydroxy-3-methylcyclopent-2-en-1-one

: 21461-89-2
(S)-(-)-tetrahydro-2-methyl-5-oxo-2-furancarboxylic acid

: 21461-86-9
(5R)-γ-valerolactone γ-carboxylic acid

: 303183-83-7
2,5-dihydroxy-5-methylcyclopent-2-en-1-one

: 2,5-dihydroxy-5-methylcyclopent-2-en-1-one

Guidance literature:: 2-hydroxy-3-methylcyclopent-2-en-1-one; With titanium(IV) isopropylate; 4 A molecular sieve; (+)-Weinsaeure-diethylester; In dichloromethane; at -20 ℃; for 0.5h;

With tert.-butylhydroperoxide; In decane; dichloromethane; at -20 ℃; for 42h; Further byproducts given. Title compound not separated from byproducts;
DOI:10.1016/S0957-4166(03)00309-4