Heptanedioic acid benzyl ester 2-((3S,7R,8R,9S)-7-benzyl-8-isobutyryloxy-9-methyl-2,6-dioxo-[1,5]dioxonan-3-ylcarbamoyl)-4-methoxy-pyridin-3-yl ester

Base Information

• Chemical Name: Heptanedioic acid benzyl ester 2-((3S,7R,8R,9S)-7-benzyl-8-isobutyryloxy-9-methyl-2,6-dioxo-[1,5]dioxonan-3-ylcarbamoyl)-4-methoxy-pyridin-3-yl ester
• CAS No.: 234113-05-4
• Molecular Formula: C₄₀H₄₆N₂O₁₂
• Molecular Weight: 746.811
• Mol file: 234113-05-4.mol

Synonyms:Heptanedioic acid benzyl ester 2-((3S,7R,8R,9S)-7-benzyl-8-isobutyryloxy-9-methyl-2,6-dioxo-[1,5]dioxonan-3-ylcarbamoyl)-4-methoxy-pyridin-3-yl ester

Chemical Property of Heptanedioic acid benzyl ester 2-((3S,7R,8R,9S)-7-benzyl-8-isobutyryloxy-9-methyl-2,6-dioxo-[1,5]dioxonan-3-ylcarbamoyl)-4-methoxy-pyridin-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Heptanedioic acid benzyl ester 2-((3S,7R,8R,9S)-7-benzyl-8-isobutyryloxy-9-methyl-2,6-dioxo-[1,5]dioxonan-3-ylcarbamoyl)-4-methoxy-pyridin-3-yl ester

There total 3 articles about Heptanedioic acid benzyl ester 2-((3S,7R,8R,9S)-7-benzyl-8-isobutyryloxy-9-methyl-2,6-dioxo-[1,5]dioxonan-3-ylcarbamoyl)-4-methoxy-pyridin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pimeloyl chloride (142-79-0) → Heptanedioic acid benzyl ester 2-((3S,7R,8R,9S)-7-benzyl-8-isobutyryloxy-9-methyl-2,6-dioxo-[1,5]dioxonan-3-ylcarbamoyl)-4-methoxy-pyridin-3-yl ester (234113-05-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂

2: Et₃N / CH₂Cl₂

With triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2005.02.065

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → Heptanedioic acid benzyl ester 2-((3S,7R,8R,9S)-7-benzyl-8-isobutyryloxy-9-methyl-2,6-dioxo-[1,5]dioxonan-3-ylcarbamoyl)-4-methoxy-pyridin-3-yl ester (234113-05-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂

2: Et₃N / CH₂Cl₂

With triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2005.02.065

Reference yield:

pimelic acid chloride monobenzyl ester (78582-38-4) + (3S,6S,7R,8R)-8-benzyl-3-{[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]amino}-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl2-methylpropanoate (167173-85-5) → Heptanedioic acid benzyl ester 2-((3S,7R,8R,9S)-7-benzyl-8-isobutyryloxy-9-methyl-2,6-dioxo-[1,5]dioxonan-3-ylcarbamoyl)-4-methoxy-pyridin-3-yl ester (234113-05-4)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2005.02.065

upstream raw materials:

pimelic acid chloride monobenzyl ester

(3S,6S,7R,8R)-8-benzyl-3-{[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]amino}-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl2-methylpropanoate

pimeloyl chloride

benzyl alcohol