ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-(2-methylpropyl)-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate

Base Information

Chemical Name:ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-(2-methylpropyl)-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate
CAS No.:863443-24-7
Molecular Formula:C₂₂H₂₃FN₂O₄
Molecular Weight:398.434
Hs Code.:

Synonyms:ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-(2-methylpropyl)-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate

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Chemical Property of ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-(2-methylpropyl)-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate

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Technology Process of ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-(2-methylpropyl)-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate

There total 3 articles about ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-(2-methylpropyl)-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 863443-21-4
ethyl 3-[[3-(ethyloxy)-3-oxopropanoyl](2-methylpropyl)amino]-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

: 863443-24-7
ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-(2-methylpropyl)-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate

Guidance literature:: With ethanol; sodium ethanolate; at 20 ℃;
DOI:10.1021/jm801404b

Reference yield:

: 863442-92-6
ethyl 3-amino-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

: 863443-24-7
ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-(2-methylpropyl)-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; 1,2-dichloro-ethane

2: dichloromethane; 1,2-dichloro-ethane

3: sodium ethanolate / ethanol

With sodium ethanolate; sodium tris(acetoxy)borohydride; acetic acid; In ethanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 863443-19-0
ethyl 5-[(4-fluorophenyl)methyl]-3-[(2-methylpropyl)amino]-2-pyridinecarboxylate

: 36239-09-5
ethyl chlorocarbonylacetate

: 863443-24-7
ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-(2-methylpropyl)-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane; 1,2-dichloro-ethane

2: sodium ethanolate / ethanol

With sodium ethanolate; In ethanol; dichloromethane; 1,2-dichloro-ethane;