ethyl 3-[[3-(ethyloxy)-3-oxopropanoyl](2-methylpropyl)amino]-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

Base Information

Chemical Name:ethyl 3-[[3-(ethyloxy)-3-oxopropanoyl](2-methylpropyl)amino]-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate
CAS No.:863443-21-4
Molecular Formula:C₂₄H₂₉FN₂O₅
Molecular Weight:444.503
Hs Code.:

Synonyms:ethyl 3-[[3-(ethyloxy)-3-oxopropanoyl](2-methylpropyl)amino]-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 3-[[3-(ethyloxy)-3-oxopropanoyl](2-methylpropyl)amino]-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

Chemical Property:

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Technology Process of ethyl 3-[[3-(ethyloxy)-3-oxopropanoyl](2-methylpropyl)amino]-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

There total 3 articles about ethyl 3-[[3-(ethyloxy)-3-oxopropanoyl](2-methylpropyl)amino]-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 863443-19-0
ethyl 5-[(4-fluorophenyl)methyl]-3-[(2-methylpropyl)amino]-2-pyridinecarboxylate

: ethyl 5-[(4-fluorophenyl)methyl]-3-[(2-methyl-1-propen-1-yl)amino]-2-pyridinecarboxylate

: 144-55-8
sodium hydrogencarbonate

: 36239-09-5
ethyl chlorocarbonylacetate

: 863443-21-4
ethyl 3-[[3-(ethyloxy)-3-oxopropanoyl](2-methylpropyl)amino]-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

Guidance literature:: In dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 863443-19-0
ethyl 5-[(4-fluorophenyl)methyl]-3-[(2-methylpropyl)amino]-2-pyridinecarboxylate

: 36239-09-5
ethyl chlorocarbonylacetate

: 863443-21-4
ethyl 3-[[3-(ethyloxy)-3-oxopropanoyl](2-methylpropyl)amino]-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

Guidance literature:: In 1,2-dichloro-ethane; Reflux;
DOI:10.1021/jm801404b

Reference yield:

: 863442-92-6
ethyl 3-amino-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

: 863443-21-4
ethyl 3-[[3-(ethyloxy)-3-oxopropanoyl](2-methylpropyl)amino]-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane; 1,2-dichloro-ethane

2: dichloromethane; 1,2-dichloro-ethane

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; 1,2-dichloro-ethane;