ethyl 5-[(4-fluorophenyl)methyl]-3-[(2-methylpropyl)amino]-2-pyridinecarboxylate

Base Information

• Chemical Name: ethyl 5-[(4-fluorophenyl)methyl]-3-[(2-methylpropyl)amino]-2-pyridinecarboxylate
• CAS No.: 863443-19-0
• Molecular Formula: C₁₉H₂₃FN₂O₂
• Molecular Weight: 330.402

Synonyms:ethyl 5-[(4-fluorophenyl)methyl]-3-[(2-methylpropyl)amino]-2-pyridinecarboxylate

Chemical Property of ethyl 5-[(4-fluorophenyl)methyl]-3-[(2-methylpropyl)amino]-2-pyridinecarboxylate

Chemical Property:

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Technology Process of ethyl 5-[(4-fluorophenyl)methyl]-3-[(2-methylpropyl)amino]-2-pyridinecarboxylate

There total 2 articles about ethyl 5-[(4-fluorophenyl)methyl]-3-[(2-methylpropyl)amino]-2-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-amino-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate (863442-92-6) + sodium hydrogencarbonate (144-55-8) + isobutyraldehyde (78-84-2) → ethyl 5-[(4-fluorophenyl)methyl]-3-[(2-methylpropyl)amino]-2-pyridinecarboxylate (863443-19-0) + ethyl 5-[(4-fluorophenyl)methyl]-3-[(2-methyl-1-propen-1-yl)amino]-2-pyridinecarboxylate

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; 1,2-dichloro-ethane;

Reference yield:

ethyl 3-amino-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate (863442-92-6) + isobutyraldehyde (78-84-2) → ethyl 5-[(4-fluorophenyl)methyl]-3-[(2-methylpropyl)amino]-2-pyridinecarboxylate (863443-19-0)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 0 - 20 ℃;

DOI:10.1021/jm801404b

Reference yield: 55.0%

ethyl 5-[(4-fluorophenyl)methyl]-3-[(2-methylpropyl)amino]-2-pyridinecarboxylate (863443-19-0) + ethyl 5-[(4-fluorophenyl)methyl]-3-[(2-methyl-1-propen-1-yl)amino]-2-pyridinecarboxylate + sodium hydrogencarbonate (144-55-8) + ethyl chlorocarbonylacetate (36239-09-5) → ethyl 3-[[3-(ethyloxy)-3-oxopropanoyl](2-methylpropyl)amino]-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate (863443-21-4)

Guidance literature:

In dichloromethane; 1,2-dichloro-ethane;

upstream raw materials:

ethyl 3-amino-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

isobutyraldehyde

sodium hydrogencarbonate

Downstream raw materials:

ethyl 3-[[3-(ethyloxy)-3-oxopropanoyl](2-methylpropyl)amino]-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-(2-methylpropyl)-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate

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