Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, 1-methylethyl ester (9CI)

Base Information

• Chemical Name: Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, 1-methylethyl ester (9CI)
• CAS No.: 197579-95-6
• Molecular Formula: C10H19 N O4
• Molecular Weight: 217.26216
• Mol file: 197579-95-6.mol

Synonyms:Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, 1-methylethyl ester (9CI)

Chemical Property of Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, 1-methylethyl ester (9CI)

Chemical Property:

• PSA: 64.63000
• LogP: 1.85360

Purity/Quality:

HPLC>98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, 1-methylethyl ester (9CI)

There total 1 articles about Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, 1-methylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

tert-butoxycarbonylamino-acetic acid benzyl ester (54244-69-8) + titanium(IV)isopropoxide (546-68-9) → N-Boc-glycine isopropylester (197579-95-6)

Guidance literature:

In benzene; at 80 ℃; for 18h;

DOI:10.1021/jo971498z

Reference yield: 100.0%

N-Boc-glycine isopropylester (197579-95-6) → glycine isopropyl ester (13048-66-3)

Guidance literature:

With methanol; 2-Bromoacetyl bromide; In dichloromethane; at 25 ℃; for 0.333333h;

DOI:10.1055/s-2002-19803

Reference yield:

3-(2,3,6-trifluorophenyl)but-3-en-2-one + N-Boc-glycine isopropylester (197579-95-6) → isopropyl (2S)-2-((tert-butoxycarbonyl)amino)-5-oxo-4-(2,3,6-trifluorophenyl)hexanoate

Guidance literature:

N-Boc-glycine isopropylester; With n-butyllithium; diisopropylamine; In 2-methyltetrahydrofuran; at -45 - -40 ℃; for 1h;

3-(2,3,6-trifluorophenyl)but-3-en-2-one; In 2-methyltetrahydrofuran; at -45 - -40 ℃;

upstream raw materials:

tert-butoxycarbonylamino-acetic acid benzyl ester

titanium(IV)isopropoxide

Downstream raw materials:

glycine isopropyl ester