2-{3-[(4-tert-butoxycarbonyl)piperazine-1-carbonyl]benzenecarbonylamino}-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide hydrochloride

Base Information

Chemical Name:2-{3-[(4-tert-butoxycarbonyl)piperazine-1-carbonyl]benzenecarbonylamino}-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide hydrochloride
CAS No.:1456905-70-6
Molecular Formula:C₃₉H₄₉N₅O₅*ClH
Molecular Weight:704.309
Hs Code.:

2-{3-[(4-tert-butoxycarbonyl)piperazine-1-carbonyl]benzenecarbonylamino}-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide hydrochloride

Synonyms:2-{3-[(4-tert-butoxycarbonyl)piperazine-1-carbonyl]benzenecarbonylamino}-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide hydrochloride

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Chemical Property of 2-{3-[(4-tert-butoxycarbonyl)piperazine-1-carbonyl]benzenecarbonylamino}-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide hydrochloride

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Technology Process of 2-{3-[(4-tert-butoxycarbonyl)piperazine-1-carbonyl]benzenecarbonylamino}-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide hydrochloride

There total 10 articles about 2-{3-[(4-tert-butoxycarbonyl)piperazine-1-carbonyl]benzenecarbonylamino}-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1395398-39-6
3-(4-tert-butoxycarbonylpiperazine-1-carbonyl)benzoic acid

: 2-amino-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide dihydrochloride

: 1456905-70-6
2-{3-[(4-tert-butoxycarbonyl)piperazine-1-carbonyl]benzenecarbonylamino}-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide hydrochloride

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 5h;
DOI:10.1002/anie.201303999

Reference yield:

: 2389-45-9
Boc-Lys(Z)-OH

: 1456905-70-6
2-{3-[(4-tert-butoxycarbonyl)piperazine-1-carbonyl]benzenecarbonylamino}-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 13.5 h / 20 °C

2: 5%-palladium/activated carbon; hydrogen / methanol / 13.5 h / 20 °C

3: hydrogenchloride; sodium nitrite; acetic acid / water; acetonitrile / 0 - 20 °C

4: triethylamine; dmap / dichloromethane / 1.5 h / -20 - 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 21.5 h / 40 °C

6: hydrogenchloride / 1,4-dioxane / 0.5 h / 0 - 20 °C

7: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 5 h / 0 - 20 °C

With hydrogenchloride; dmap; 5%-palladium/activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/anie.201303999

Reference yield:

: 1456905-65-9
2-(N-tert-butoxycarbonylamino)-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide

: 1456905-70-6
2-{3-[(4-tert-butoxycarbonyl)piperazine-1-carbonyl]benzenecarbonylamino}-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 0.5 h / 0 - 20 °C

2: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 5 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201303999