α-ethenyl-α-[(3-(trifluoromethyl)phenyl)]-3'-(trifluoromethyl)benzenemethanol

Base Information

• Chemical Name: α-ethenyl-α-[(3-(trifluoromethyl)phenyl)]-3'-(trifluoromethyl)benzenemethanol
• CAS No.: 1116366-14-3
• Molecular Formula: C₁₇H₁₂F₆O
• Molecular Weight: 346.272
• Mol file: 1116366-14-3.mol

Synonyms:α-ethenyl-α-[(3-(trifluoromethyl)phenyl)]-3'-(trifluoromethyl)benzenemethanol

Chemical Property of α-ethenyl-α-[(3-(trifluoromethyl)phenyl)]-3'-(trifluoromethyl)benzenemethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-ethenyl-α-[(3-(trifluoromethyl)phenyl)]-3'-(trifluoromethyl)benzenemethanol

There total 4 articles about α-ethenyl-α-[(3-(trifluoromethyl)phenyl)]-3'-(trifluoromethyl)benzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3'-bis(trifluoromethyl)benzophenone (1868-00-4) + vinyl magnesium bromide (1826-67-1) → α-ethenyl-α-[(3-(trifluoromethyl)phenyl)]-3'-(trifluoromethyl)benzenemethanol (1116366-14-3)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 3h;

DOI:10.1002/anie.201302673

Reference yield:

3,3'-bis(trifluoromethyl)benzhydrol (1598-89-6) → α-ethenyl-α-[(3-(trifluoromethyl)phenyl)]-3'-(trifluoromethyl)benzenemethanol (1116366-14-3)

Guidance literature:

Multi-step reaction with 2 steps

1: silica gel; pyridinium chlorochromate / dichloromethane / 20 °C

2: tetrahydrofuran / 60 °C / Inert atmosphere

With silica gel; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.cclet.2019.08.011

Reference yield:

3-Trifluoromethylbenzaldehyde (454-89-7) → α-ethenyl-α-[(3-(trifluoromethyl)phenyl)]-3'-(trifluoromethyl)benzenemethanol (1116366-14-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: magnesium / diethyl ether / 2 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: silica gel; pyridinium chlorochromate / dichloromethane / 20 °C

3.1: tetrahydrofuran / 60 °C / Inert atmosphere

With silica gel; magnesium; pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1016/j.cclet.2019.08.011

upstream raw materials:

3,3'-bis(trifluoromethyl)benzophenone

vinyl magnesium bromide

3,3'-bis(trifluoromethyl)benzhydrol

3-Trifluoromethylbenzaldehyde

Downstream raw materials:

4,4,4-trifluoro-1,2-di-[(3-trifluoromethyl)phenyl]-1-butanone

3-(diphenylphosphoryl)-1,2-bis(3-(trifluoromethyl)phenyl)propan-1-one

C₂₇H₁₈F₆O