4-(3-ethoxy-4-(methoxymethoxy)-5-nitrophenyl)-5,6-diphenyl-3,4-dihydropyridin-2(1H)-one

Base Information

• Chemical Name: 4-(3-ethoxy-4-(methoxymethoxy)-5-nitrophenyl)-5,6-diphenyl-3,4-dihydropyridin-2(1H)-one
• CAS No.: 1356060-13-3
• Molecular Formula: C₂₇H₂₆N₂O₆
• Molecular Weight: 474.513
• Mol file: 1356060-13-3.mol

Synonyms:4-(3-ethoxy-4-(methoxymethoxy)-5-nitrophenyl)-5,6-diphenyl-3,4-dihydropyridin-2(1H)-one

Chemical Property of 4-(3-ethoxy-4-(methoxymethoxy)-5-nitrophenyl)-5,6-diphenyl-3,4-dihydropyridin-2(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-ethoxy-4-(methoxymethoxy)-5-nitrophenyl)-5,6-diphenyl-3,4-dihydropyridin-2(1H)-one

There total 3 articles about 4-(3-ethoxy-4-(methoxymethoxy)-5-nitrophenyl)-5,6-diphenyl-3,4-dihydropyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5,6-diphenyl-3,4-dihydropyridin-2(1H)-one (1356059-92-1) + chloromethyl methyl ether (107-30-2) → 4-(3-ethoxy-4-(methoxymethoxy)-5-nitrophenyl)-5,6-diphenyl-3,4-dihydropyridin-2(1H)-one (1356060-13-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 2h;

Reference yield:

3-ethoxy-4-hydroxy-5-nitrobenzaldehyde (178686-24-3) → 4-(3-ethoxy-4-(methoxymethoxy)-5-nitrophenyl)-5,6-diphenyl-3,4-dihydropyridin-2(1H)-one (1356060-13-3)

Guidance literature:

Multi-step reaction with 2 steps

1: cycl-isopropylidene malonate; acetic acid / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 25 °C

With cycl-isopropylidene malonate; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;

Reference yield:

phenyl benzyl ketone (451-40-1) → 4-(3-ethoxy-4-(methoxymethoxy)-5-nitrophenyl)-5,6-diphenyl-3,4-dihydropyridin-2(1H)-one (1356060-13-3)

Guidance literature:

Multi-step reaction with 2 steps

1: cycl-isopropylidene malonate; acetic acid / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 25 °C

With cycl-isopropylidene malonate; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;

upstream raw materials:

4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5,6-diphenyl-3,4-dihydropyridin-2(1H)-one

chloromethyl methyl ether

3-ethoxy-4-hydroxy-5-nitrobenzaldehyde

phenyl benzyl ketone

Downstream raw materials:

4-(3-ethoxy-4-(methoxymethoxy)-5-nitrophenyl)-1-methyl-5,6-diphenyl-3,4-dihydropyridin-2(1H)-one