Methanesulfonic acid (diethoxy-phosphoryl)-p-tolyl-methyl ester

Base Information

• Chemical Name: Methanesulfonic acid (diethoxy-phosphoryl)-p-tolyl-methyl ester
• CAS No.: 96258-46-7
• Molecular Formula: C₁₃H₂₁O₆PS
• Molecular Weight: 336.346
• Mol file: 96258-46-7.mol

Synonyms:Methanesulfonic acid (diethoxy-phosphoryl)-p-tolyl-methyl ester

Chemical Property of Methanesulfonic acid (diethoxy-phosphoryl)-p-tolyl-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (diethoxy-phosphoryl)-p-tolyl-methyl ester

There total 5 articles about Methanesulfonic acid (diethoxy-phosphoryl)-p-tolyl-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl hydroxy(p-tolyl)methylphosphonate (79158-40-0) + methanesulfonyl chloride (124-63-0) → Methanesulfonic acid (diethoxy-phosphoryl)-p-tolyl-methyl ester (96258-46-7)

Guidance literature:

With triethylamine; In dichloromethane; at -30 - 0 ℃;

DOI:10.1021/jo00212a033

Reference yield:

diethyl α-trimethylsilyloxy-4-methylbenzylphosphonate (96258-65-0) → Methanesulfonic acid (diethoxy-phosphoryl)-p-tolyl-methyl ester (96258-46-7)

Guidance literature:

Multi-step reaction with 2 steps

1: CF₃CO₂H / methanol / Ambient temperature

2: Et₃N / CH₂Cl₂ / -30 - 0 °C

With triethylamine; trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1021/jo00212a033

Reference yield:

4-methyl-benzaldehyde (104-87-0) → Methanesulfonic acid (diethoxy-phosphoryl)-p-tolyl-methyl ester (96258-46-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 °C / Heating

2: CF₃CO₂H / methanol / Ambient temperature

3: Et₃N / CH₂Cl₂ / -30 - 0 °C

With triethylamine; trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1021/jo00212a033

upstream raw materials:

diethyl hydroxy(p-tolyl)methylphosphonate

methanesulfonyl chloride

Diethyl phosphonate

4-methyl-benzaldehyde

Downstream raw materials:

(Hydrazino-p-tolyl-methyl)-phosphonic acid diethyl ester

diethyl (1-acetoxy)(4-methylphenyl)methylphosphonate