1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)ethanone

Base Information

Chemical Name:1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)ethanone
CAS No.:1416163-70-6
Molecular Formula:C₁₉H₁₇F₂N₃O₃
Molecular Weight:373.359
Hs Code.:

Synonyms:1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)ethanone

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Chemical Property of 1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)ethanone

Chemical Property:

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Technology Process of 1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)ethanone

There total 1 articles about 1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86386-76-7,123632-22-4,141113-42-0,150024-48-9
1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole

: 99-93-4
4-Hydroxyacetophenone

: 1416163-70-6
1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)ethanone

Guidance literature:: With tetrabutylammomium bromide; potassium carbonate; In ethyl acetate; for 12h; Inert atmosphere; Reflux;

Reference yield: 82.3%

: 1416163-70-6
1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)ethanone

: 874-42-0
2,4-dichlorobenzaldeyhde

: 1416163-69-3
(E)-3-(2,4-dichlorophenyl)-1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)prop-2-en-1-one

Guidance literature:: With sodium hydroxide; In methanol; water; at 20 ℃; for 18h;

Reference yield:

: 1416163-70-6
1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)ethanone

: 1416163-98-8
2,3-dibromo-3-(2,4-dichlorophenyl)-1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)propan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; methanol / 18 h / 20 °C

2: bromine / chloroform / 12 h

With bromine; sodium hydroxide; In methanol; chloroform; water;