(1S,2R)-1,2-diphenyl-2-methoxyethanol

Base Information

• Chemical Name: (1S,2R)-1,2-diphenyl-2-methoxyethanol
• CAS No.: 247905-12-0
• Molecular Formula: C₁₅H₁₆O₂
• Molecular Weight: 228.291
• Mol file: 247905-12-0.mol

Synonyms:(1S,2R)-1,2-diphenyl-2-methoxyethanol

Chemical Property of (1S,2R)-1,2-diphenyl-2-methoxyethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R)-1,2-diphenyl-2-methoxyethanol

There total 4 articles about (1S,2R)-1,2-diphenyl-2-methoxyethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzoin monomethyl ether (3524-62-7) → (1S,2R)-1,2-diphenyl-2-methoxyethanol (247905-12-0) + (+)-erythro-α,β-diphenyl-β-hydroxyethanol methyl ether (118353-44-9)

Guidance literature:

With Amberlite IRA-900; hydrogen; Pt/Al₂O₃; 10,11-dihydrocinchonidine; In toluene; at 25 ℃; for 1.05h; under 45004.5 Torr; Further Variations:; Catalysts; Reagents; Product distribution; Kinetics;

DOI:10.1002/1615-4169(200207)344:5<511::AID-ADSC511>3.0.CO;2-D

Reference yield:

benzoin monomethyl ether (3524-62-7) → (1S,2R)-1,2-diphenyl-2-methoxyethanol (247905-12-0) + (1R,2R)-2-methoxy-1,2-diphenylethan-1-ol (115889-24-2) + (+)-erythro-α,β-diphenyl-β-hydroxyethanol methyl ether (118353-44-9)

Guidance literature:

With formic acid; triethylamine; RuCl[(1S,2S)-TsDPEN](η⁶-p-cymene); at 40 ℃; for 24h;

DOI:10.1021/ol990226a

Reference yield:

benzyl methyl ether (538-86-3) + benzaldehyde (100-52-7) → (1S,2R)-1,2-diphenyl-2-methoxyethanol (247905-12-0) + (1R,2R)-2-methoxy-1,2-diphenylethan-1-ol (115889-24-2) + (+)-erythro-α,β-diphenyl-β-hydroxyethanol methyl ether (118353-44-9) + (1S,2S)-2-methoxy-1,2-diphenylethan-1-ol (118353-46-1)

Guidance literature:

With tert.-butyl lithium; (4S)-2,2'-(1-Ethylpropylidene)bis<4-(1-methylethyl)-4,5-dihydrooxazole>; In hexane; at -110 - -78 ℃; for 2.5h;

DOI:10.1016/S0040-4039(99)01365-9

upstream raw materials:

benzyl methyl ether

benzaldehyde

benzoin monomethyl ether

Downstream raw materials:

(1R,2S)-1,2-dimethoxy-1,2-diphenylethane