2,2-Dimethyl-N-[4-methyl-2-(2,2,2-trifluoro-acetyl)-phenyl]-propionamide

Base Information

Chemical Name:2,2-Dimethyl-N-[4-methyl-2-(2,2,2-trifluoro-acetyl)-phenyl]-propionamide
CAS No.:205756-34-9
Molecular Formula:C₁₄H₁₆F₃NO₂
Molecular Weight:287.282
Hs Code.:

Synonyms:2,2-Dimethyl-N-[4-methyl-2-(2,2,2-trifluoro-acetyl)-phenyl]-propionamide

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Chemical Property of 2,2-Dimethyl-N-[4-methyl-2-(2,2,2-trifluoro-acetyl)-phenyl]-propionamide

Chemical Property:

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Technology Process of 2,2-Dimethyl-N-[4-methyl-2-(2,2,2-trifluoro-acetyl)-phenyl]-propionamide

There total 6 articles about 2,2-Dimethyl-N-[4-methyl-2-(2,2,2-trifluoro-acetyl)-phenyl]-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 383-63-1
ethyl trifluoroacetate,

: 205756-33-8
N-(2-iodo-4-methylphenyl)pivalamide

: 205756-34-9
2,2-Dimethyl-N-[4-methyl-2-(2,2,2-trifluoro-acetyl)-phenyl]-propionamide

Guidance literature:: N-(2-iodo-4-methylphenyl)pivalamide; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

ethyl trifluoroacetate,; In tetrahydrofuran;
DOI:10.1016/S0960-894X(99)00486-2

Reference yield:

: 383-63-1
ethyl trifluoroacetate,

: 21354-40-5
2,2-dimethyl-N-(4-methylphenyl)propanamide

: 205756-34-9
2,2-Dimethyl-N-[4-methyl-2-(2,2,2-trifluoro-acetyl)-phenyl]-propionamide

Guidance literature:: 2,2-dimethyl-N-(4-methylphenyl)propanamide; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In hexane; tert-butyl methyl ether; at -20 - 15 ℃; for 6h;

ethyl trifluoroacetate,; at -25 - 20 ℃; for 16h;
DOI:10.1021/acs.joc.7b01235

Reference yield:

: 29289-13-2
2-iodo-4-methylaniline

: 205756-34-9
2,2-Dimethyl-N-[4-methyl-2-(2,2,2-trifluoro-acetyl)-phenyl]-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / TEA / CH₂Cl₂ / 3 h / 25 °C

2.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

2.2: 13 percent / tetrahydrofuran

With n-butyllithium; TEA; In tetrahydrofuran; dichloromethane; 1.1: Acylation / 2.1: Metallation / 2.2: Acylation;
DOI:10.1016/S0960-894X(99)00486-2