2-(3-((2R,3S,4R,5R)-3-(tert-butoxycarbonyloxy)-4-(tetrahydro-2H-pyran-2-yloxy)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate

Base Information

Chemical Name:2-(3-((2R,3S,4R,5R)-3-(tert-butoxycarbonyloxy)-4-(tetrahydro-2H-pyran-2-yloxy)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate
CAS No.:1054490-24-2
Molecular Formula:C₃₄H₄₈N₂O₁₃S
Molecular Weight:724.827
Hs Code.:

2-(3-((2R,3S,4R,5R)-3-(tert-butoxycarbonyloxy)-4-(tetrahydro-2H-pyran-2-yloxy)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate

Synonyms:2-(3-((2R,3S,4R,5R)-3-(tert-butoxycarbonyloxy)-4-(tetrahydro-2H-pyran-2-yloxy)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate

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Chemical Property of 2-(3-((2R,3S,4R,5R)-3-(tert-butoxycarbonyloxy)-4-(tetrahydro-2H-pyran-2-yloxy)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate

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Technology Process of 2-(3-((2R,3S,4R,5R)-3-(tert-butoxycarbonyloxy)-4-(tetrahydro-2H-pyran-2-yloxy)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate

There total 5 articles about 2-(3-((2R,3S,4R,5R)-3-(tert-butoxycarbonyloxy)-4-(tetrahydro-2H-pyran-2-yloxy)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22423-26-3
O-2,2'-cyclo-5-methyluridine

: 1054490-24-2
2-(3-((2R,3S,4R,5R)-3-(tert-butoxycarbonyloxy)-4-(tetrahydro-2H-pyran-2-yloxy)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / acetonitrile / 20 °C / Molecular sieve

2: sodium hydroxide / methanol / 6 h / 20 °C

3: triethylamine / dmap / dichloromethane / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C

5: triethylamine / dichloromethane / 2 h

With sodium hydroxide; potassium carbonate; triethylamine; dmap; toluene-4-sulfonic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 351523-06-3
(2R,3R,3aS,9aR)-7-Methyl-3-(tetrahydro-pyran-2-yloxy)-2-(tetrahydro-pyran-2-yloxymethyl)-2,3,3a,9a-tetrahydro-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one

: 1054490-24-2
2-(3-((2R,3S,4R,5R)-3-(tert-butoxycarbonyloxy)-4-(tetrahydro-2H-pyran-2-yloxy)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / methanol / 6 h / 20 °C

2: triethylamine / dmap / dichloromethane / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C

4: triethylamine / dichloromethane / 2 h

With sodium hydroxide; potassium carbonate; triethylamine; dmap; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1463-10-1,642082-80-2
5-Methyluridine

: 1054490-24-2
2-(3-((2R,3S,4R,5R)-3-(tert-butoxycarbonyloxy)-4-(tetrahydro-2H-pyran-2-yloxy)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)tetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)ethyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: bis(phenyl) carbonate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 150 °C

2: toluene-4-sulfonic acid / acetonitrile / 20 °C / Molecular sieve

3: sodium hydroxide / methanol / 6 h / 20 °C

4: triethylamine / dmap / dichloromethane / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C

6: triethylamine / dichloromethane / 2 h

With bis(phenyl) carbonate; sodium hydroxide; sodium hydrogencarbonate; potassium carbonate; triethylamine; dmap; toluene-4-sulfonic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;