6-(3,4-dichlorophenyl)pyrimidine-4-carboxylic acid methyl ester

Base Information

• Chemical Name: 6-(3,4-dichlorophenyl)pyrimidine-4-carboxylic acid methyl ester
• CAS No.: 1207723-46-3
• Molecular Formula: C₁₂H₈Cl₂N₂O₂
• Molecular Weight: 283.114
• Mol file: 1207723-46-3.mol

Synonyms:6-(3,4-dichlorophenyl)pyrimidine-4-carboxylic acid methyl ester

Chemical Property of 6-(3,4-dichlorophenyl)pyrimidine-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 6-(3,4-dichlorophenyl)pyrimidine-4-carboxylic acid methyl ester

There total 2 articles about 6-(3,4-dichlorophenyl)pyrimidine-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 4-chloro-6-(3,4-dichloro-phenyl)-pyrimidine (954224-40-9) → 6-(3,4-dichlorophenyl)pyrimidine-4-carboxylic acid methyl ester (1207723-46-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; at 50 ℃; for 18h; under 3750.38 Torr; Autoclave; Inert atmosphere; Sealed tube;

DOI:10.1021/jm501350y

Reference yield:

→ 6-(3,4-dichlorophenyl)pyrimidine-4-carboxylic acid methyl ester (1207723-46-3)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; at 50 ℃; for 5h; under 3750.38 Torr; Inert atmosphere;

Reference yield: 66.0%

6-(3,4-dichlorophenyl)pyrimidine-4-carboxylic acid methyl ester (1207723-46-3) → 6-(3,4-dichlorophenyl)pyrimidine-4-carboxylic acid sodium salt (1207723-56-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/jm501350y

upstream raw materials:

methanol

carbon monoxide

4-chloro-6-(3,4-dichloro-phenyl)-pyrimidine

Downstream raw materials:

6-(3,4-dichlorophenyl)pyrimidine-4-carboxylic acid sodium salt

N-[6-(3,4-dichloro-phenyl)-pyrimidine-4-carbonyl]-benzenesulfonamide