ethyl ({[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate

Base Information

• Chemical Name: ethyl ({[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate
• CAS No.: 714249-31-7
• Molecular Formula: C₂₈H₃₂N₄O₄S
• Molecular Weight: 520.652
• Mol file: 714249-31-7.mol

Synonyms:ethyl ({[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate

Chemical Property of ethyl ({[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl ({[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate

There total 11 articles about ethyl ({[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl 2-(chlorosulfonyl)acetate (55896-93-0) + 7-({[4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}methyl)-2-naphthonitrile (771584-73-7) → ethyl ({[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate (714249-31-7)

Guidance literature:

With pyridine; In 1,2-dichloro-ethane; at 20 ℃; for 17h;

DOI:10.1016/j.bmc.2004.07.046

Reference yield:

1-Methylhomopiperazine (4318-37-0) → ethyl ({[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate (714249-31-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 69 percent / K₂CO₃ / dimethylformamide / 17 h / 100 °C

2: H₂ / Pd/C / ethanol / 2 h / 20 °C

3: AcOH; NaB(OAc)3H / CH₂Cl₂ / 2 h / 20 °C

4: 80 percent / pyridine / 1,2-dichloro-ethane / 17 h / 20 °C

With pyridine; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; palladium on activated charcoal; In ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2004.07.046

Reference yield:

4-Fluoronitrobenzene (350-46-9,178603-76-4) → ethyl ({[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate (714249-31-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 83 percent / potassium carbonate / dimethylformamide / 13 h / 90 °C

2: H₂ / Pd/C / ethanol / 16 h / 20 °C

3: 15.8 g / acetic acid; sodium triacetoxyborohydride / 1,2-dichloro-ethane / 5 h

4: 87 percent / pyridine / 1,2-dichloro-ethane / 12 h / 20 °C

5: trifluoroacetic acid / CH₂Cl₂ / 3 h / 20 °C

6: 480 mg / sodium triacetoxyborohydride; acetic acid / 1,2-dichloro-ethane; H₂O / 2 h

With pyridine; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2004.02.022

upstream raw materials:

ethyl 2-(chlorosulfonyl)acetate

7-({[4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}methyl)-2-naphthonitrile

formaldehyd

4-Fluoronitrobenzene