Technology Process of 1,1-Dimethylethyl (2S)-2-(3-oxobutyl)-1-pyrrolidinecarboxylate
There total 1 articles about 1,1-Dimethylethyl (2S)-2-(3-oxobutyl)-1-pyrrolidinecarboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl pyrrolidine-1-carboxylate;
With
sec.-butyllithium; (-)-sparteine;
In
diethyl ether;
at -78 ℃;
for 1h;
With
lithium chloride;
In
tetrahydrofuran; diethyl ether;
at -78 ℃;
for 1h;
methyl vinyl ketone;
With
chloro-trimethyl-silane;
In
tetrahydrofuran; diethyl ether;
at -78 - 25 ℃;
for 42h;
Title compound not separated from byproducts;
DOI:10.1021/jo035845i
- Guidance literature:
-
In
tetrahydrofuran;
at 0 - 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 70 percent / KHMDS / tetrahydrofuran
2: 100 percent / TFA / CH2Cl2 / 20 °C
3: 70 percent / AcOH; NaBH(OAc)3 / tetrahydrofuran
4: 64 percent / KHMDS / diethyl ether / 20 °C
5: 41 percent / cyclic Pd-compound / acetonitrile; dimethylformamide; H2O / 2 h / 120 °C
With
potassium hexamethylsilazane; sodium tris(acetoxy)borohydride; acetic acid; trifluoroacetic acid;
cyclic Pd-compound;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4039(02)01219-4
