6-[4-(4-tert-butylcyclohexyl)-1,4-diazepan-1-yl]-N-(pyridin-3-ylmethyl)pyridine-2-carboxamide

Base Information

Chemical Name:6-[4-(4-tert-butylcyclohexyl)-1,4-diazepan-1-yl]-N-(pyridin-3-ylmethyl)pyridine-2-carboxamide
CAS No.:1373270-97-3
Molecular Formula:C₂₇H₃₉N₅O
Molecular Weight:449.64
Hs Code.:

Synonyms:6-[4-(4-tert-butylcyclohexyl)-1,4-diazepan-1-yl]-N-(pyridin-3-ylmethyl)pyridine-2-carboxamide

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Chemical Property of 6-[4-(4-tert-butylcyclohexyl)-1,4-diazepan-1-yl]-N-(pyridin-3-ylmethyl)pyridine-2-carboxamide

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Technology Process of 6-[4-(4-tert-butylcyclohexyl)-1,4-diazepan-1-yl]-N-(pyridin-3-ylmethyl)pyridine-2-carboxamide

There total 6 articles about 6-[4-(4-tert-butylcyclohexyl)-1,4-diazepan-1-yl]-N-(pyridin-3-ylmethyl)pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

: 3731-52-0
3-Aminomethylpyridine

: 1373272-10-6
6-[4-(4-tert-butylcyclohexyl)-1,4-diazepan-1-yl]pyridine-2-carboxylic acid

: 1373270-97-3
6-[4-(4-tert-butylcyclohexyl)-1,4-diazepan-1-yl]-N-(pyridin-3-ylmethyl)pyridine-2-carboxamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 1373271-56-7
tert-butyl 6-(1,4-diazepan-1-yl)pyridine-2-carboxylate

: 1373270-97-3
6-[4-(4-tert-butylcyclohexyl)-1,4-diazepan-1-yl]-N-(pyridin-3-ylmethyl)pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 72 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 192 h / 20 °C

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 20 °C

With sodium tris(acetoxy)borohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 80099-98-5
6-chloropicolinoyl chloride

: 1373270-97-3
6-[4-(4-tert-butylcyclohexyl)-1,4-diazepan-1-yl]-N-(pyridin-3-ylmethyl)pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 18 h / 20 °C

2: N,N-dimethyl acetamide / 0.58 h / 180 °C / Microwave irradiation

3: sodium tris(acetoxy)borohydride / dichloromethane / 72 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 192 h / 20 °C

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 20 °C

With sodium tris(acetoxy)borohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;