1-BOC-4-(2-CBZ-AMINO-2-METHOXYCARBONYL-ETHYL)PIPERIDINE

Base Information

• Chemical Name: 1-BOC-4-(2-CBZ-AMINO-2-METHOXYCARBONYL-ETHYL)PIPERIDINE
• CAS No.: 195877-39-5
• Molecular Formula: C22H32 N2 O6
• Molecular Weight: 420.5
• Hs Code.: 2933399090
• Mol file: 195877-39-5.mol

Synonyms:1-BOC-4-(2-CBZ-AMINO-2-METHOXYCARBONYL-ETHYL)PIPERIDINE

Chemical Property of 1-BOC-4-(2-CBZ-AMINO-2-METHOXYCARBONYL-ETHYL)PIPERIDINE

Chemical Property:

• PSA: 94.17000
• LogP: 3.82040

Purity/Quality:

NLT 98% ^*data from raw suppliers

tert-Butyl4-(2-(((benzyloxy)carbonyl)amino)-3-methoxy-3-oxopropyl)piperidine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-BOC-4-(2-CBZ-AMINO-2-METHOXYCARBONYL-ETHYL)PIPERIDINE

There total 1 articles about 1-BOC-4-(2-CBZ-AMINO-2-METHOXYCARBONYL-ETHYL)PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methanol (67-56-1) + 4-(2-benzyloxycarbonylamino-2-carboxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester (195877-38-4) → 4-(2-benzyloxycarbonylamino-2-methoxycarbonyl-ethyl)-piperidine-1-carboxylic acid tert-butyl ester (195877-39-5)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; for 1.5h; Ambient temperature;

DOI:10.1016/S0960-894X(99)00179-1

Reference yield: 100.0%

4-(2-benzyloxycarbonylamino-2-methoxycarbonyl-ethyl)-piperidine-1-carboxylic acid tert-butyl ester (195877-39-5) → 4-(2-benzyloxycarbonylamino-3-oxo-propyl)-piperidine-1-carboxylic acid tert-butyl ester (229474-82-2)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 1h;

DOI:10.1016/S0960-894X(99)00179-1

Reference yield:

4-(2-benzyloxycarbonylamino-2-methoxycarbonyl-ethyl)-piperidine-1-carboxylic acid tert-butyl ester (195877-39-5) → 3-{[(S)-1-((R)-3-Cyclohexyl-2-ethanesulfonylamino-propionyl)-pyrrolidine-2-carbonyl]-amino}-2-oxo-4-piperidin-4-yl-butyric acid

Guidance literature:

Multi-step reaction with 9 steps

1: 100 percent / DIBAL-H / CH₂Cl₂ / 1 h / -78 °C

2: 100 percent / TEBAC / CH₂Cl₂; H₂O / 0.5 h / 0 °C

3: 89 percent / HCl (gas) / diethyl ether / 16 h / 0 - 5 °C

4: 45 percent / Et₃N, pH 8.5 / dimethylformamide / 1 h / Ambient temperature

5: 100 percent / H₂ / 10 percent Pd/C / dimethylformamide / Ambient temperature

6: 88 percent / HOBT, DCCI / dimethylformamide / a) 0 deg C, 0.5 h, b) RT, 16 h

7: 100 percent / 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one / CH₂Cl₂ / 0.5 h / Ambient temperature

8: 100 percent / pH 11.5 / dioxane; H₂O / Ambient temperature

9: 36 percent / TFA / CH₂Cl₂ / 1 h / Ambient temperature

With hydrogenchloride; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; diisobutylaluminium hydride; benzotriazol-1-ol; Dess-Martin periodane; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In 1,4-dioxane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(99)00179-1

upstream raw materials:

methanol

4-(2-benzyloxycarbonylamino-2-carboxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

4-(2-benzyloxycarbonylamino-3-oxo-propyl)-piperidine-1-carboxylic acid tert-butyl ester

3-benzyloxycarbonylamino-2-hydroxy-4-piperidin-4-yl-butyric acid methyl ester

4-(2-benzyloxycarbonylamino-3-hydroxy-3-methoxycarbonyl-propyl)-piperidine-1-carboxylic acid tert-butyl ester

4-(3-acetoxy-2-benzyloxycarbonylamino-3-cyano-propyl)-piperidine-1-carboxylic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 195877-39-5 1-BOC-4-(2-CBZ-AMINO-2-METHOXYCARBONYL-ETHYL)PIPERIDINE

Send

Send

Metric Ton KG G Pound L ML

Send

Send