diisopropyl 1-(4-bromobenzoyl)hydrazine-1,2-dicarboxylate

Base Information

• Chemical Name: diisopropyl 1-(4-bromobenzoyl)hydrazine-1,2-dicarboxylate
• CAS No.: 1340546-31-7
• Molecular Formula: C₁₅H₁₉BrN₂O₅
• Molecular Weight: 387.23
• Mol file: 1340546-31-7.mol

Synonyms:diisopropyl 1-(4-bromobenzoyl)hydrazine-1,2-dicarboxylate

Chemical Property of diisopropyl 1-(4-bromobenzoyl)hydrazine-1,2-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diisopropyl 1-(4-bromobenzoyl)hydrazine-1,2-dicarboxylate

There total 1 articles about diisopropyl 1-(4-bromobenzoyl)hydrazine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

di-isopropyl azodicarboxylate (2446-83-5) + 4-bromo-benzaldehyde (1122-91-4) → diisopropyl 1-(4-bromobenzoyl)hydrazine-1,2-dicarboxylate (1340546-31-7)

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; at 140 ℃; for 0.166667h; Microwave irradiation; Sealed tube;

DOI:10.1016/j.tetlet.2014.11.090

Reference yield: 80.0%

diisopropyl 1-(4-bromobenzoyl)hydrazine-1,2-dicarboxylate (1340546-31-7) → C11H12BrNO3

Guidance literature:

diisopropyl 1-(4-bromobenzoyl)hydrazine-1,2-dicarboxylate; With sodium hydride; In tetrahydrofuran; mineral oil;

With bromoacetic acid tert-butyl ester; In tetrahydrofuran; mineral oil; at 25 ℃; for 16h;

DOI:10.1039/c7ra04178k

Reference yield: 79.0%

diisopropyl 1-(4-bromobenzoyl)hydrazine-1,2-dicarboxylate (1340546-31-7) + n-pentylmagnesium bromide (693-25-4) → 1-(4-bromophenyl)-1-hexanone (7295-46-7)

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

DOI:10.1039/c3cc47967f

upstream raw materials:

di-isopropyl azodicarboxylate

4-bromo-benzaldehyde

Downstream raw materials:

1-(4-bromophenyl)-1-hexanone

(4-bromophenyl)(phenyl)methanone

n-butyl 4-bromobenzoate

N-allyl-4-bromobenzamide

Refernces

• 1、 Mariappan, Arumugam,Rajaguru, Kandasamy,Muthusubramanian, Shanmugam,Bhuvanesh, Nattamai. "A new facile pyridine-catalyzed hydroacylation of aldehydes with azodicarboxylates under microwave irradiation". . p. 338 - 341. Retrieved 2015.
• 2、 Papadopoulos, Giorgos N.,Kokotos, Christoforos G.. "One-Pot Amide Bond Formation from Aldehydes and Amines via a Photoorganocatalytic Activation of Aldehydes". . p. 7023 - 7028. Retrieved 2016/08/30.