3-(6-(Dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine

Base Information

Chemical Name:3-(6-(Dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine
CAS No.:195055-03-9
Deprecated CAS:292073-75-7
Molecular Formula:C₂₂H₃₂N₆
Molecular Weight:380.536
Hs Code.:2933990090
UNII:G82N555U1N
DSSTox Substance ID:DTXSID00173162
Nikkaji Number:J1.775.143C
Wikidata:Q27088503
Pharos Ligand ID:46P5BXHLK5CU
ChEMBL ID:CHEMBL309138
Mol file:195055-03-9.mol

Synonyms:NBI 30775;R 121919;R-121919;R121919

Suppliers and Price of 3-(6-(Dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine
10mg
$ 1260.00

Matrix Scientific
3-(6-(Dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine 95+%
250mg
$ 3780.00

DC Chemicals
R121919 >98%
1 g
$ 3600.00

DC Chemicals
R121919 >98%
250 mg
$ 1800.00

Crysdot
R121919 95+%
10mg
$ 243.00

Crysdot
R121919 95+%
5mg
$ 139.00

Crysdot
R121919 95+%
50mg
$ 832.00

Crysdot
R121919 95+%
25mg
$ 485.00

ChemScene
R121919 99.84%
50mg
$ 1440.00

ChemScene
R121919 99.84%
25mg
$ 840.00

Total 24 raw suppliers

Chemical Property of 3-(6-(Dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine

Chemical Property:

Refractive Index:1.595
PSA：49.56000
Density:1.114g/cm³
LogP:4.40890
XLogP3:4.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:380.26884505
Heavy Atom Count:28
Complexity:480

Purity/Quality:

97% ^*data from raw suppliers

3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCN(CCC)C1=CC(=NC2=C(C(=NN12)C)C3=CN=C(C=C3C)N(C)C)C
Uses 3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine, is a potent and Orally active Corticotropin-Releasing factor 1 receptor antagonists, which is hown to reduce negative emotional symptoms of acute and protracted alcohol withdrawal, and thus used for the treatment of alcoholism.

Technology Process of 3-(6-(Dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine

There total 9 articles about 3-(6-(Dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 142-84-7
di-n-propylamine

: 195055-65-3
3-(4-methyl-6-dimethylaminopyridin-3-yl)-2,5-dimethyl-7-chloropyrazolo[1,5-a]pyrimidine

: 195055-03-9
3-[6-(dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[2,3-a]pyrimidine-7-amine

Guidance literature:: In acetonitrile; for 3h; Heating;
DOI:10.1021/jm040058e

Reference yield:

: 20173-72-2
2-(N,N-dimethylamino)-4-methylpyridine

: 195055-03-9
3-[6-(dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[2,3-a]pyrimidine-7-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: Br₂; aq. Na₂CO₃ / CH₂Cl₂ / 0.5 h / 0 °C

2.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 0.5 h

2.2: 77 percent / tetrahydrofuran / 20 °C

3.1: KOtBu / 1,2-dimethoxy-ethane / 0.17 h / -50 °C

3.2: 80 percent / 1,2-dimethoxy-ethane / 0.5 h / -50 °C

4.1: 80 percent / NaH / tetrahydrofuran / 20 °C

5.1: 93 percent / hydrazine hydrobromide / ethanol; H₂O / 1 h / Heating

6.1: 62 percent / dioxane / 20 h / Heating

7.1: 99 percent / POCl₃ / acetonitrile / 8 h / Heating

8.1: 72 percent / acetonitrile / 3 h / Heating

With hydrazine monohydrobromide; potassium tert-butylate; bromine; sodium hydride; sodium carbonate; magnesium; ethylene dibromide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm040058e

Reference yield:

: 764651-69-6
2-dimethylamino-4-methyl-5-formylpyridine

: 195055-03-9
3-[6-(dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[2,3-a]pyrimidine-7-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: KOtBu / 1,2-dimethoxy-ethane / 0.17 h / -50 °C

1.2: 80 percent / 1,2-dimethoxy-ethane / 0.5 h / -50 °C

2.1: 80 percent / NaH / tetrahydrofuran / 20 °C

3.1: 93 percent / hydrazine hydrobromide / ethanol; H₂O / 1 h / Heating

4.1: 62 percent / dioxane / 20 h / Heating

5.1: 99 percent / POCl₃ / acetonitrile / 8 h / Heating

6.1: 72 percent / acetonitrile / 3 h / Heating

With hydrazine monohydrobromide; potassium tert-butylate; sodium hydride; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; acetonitrile;
DOI:10.1021/jm040058e