N,N,4-TRIMETHYL-2-PYRIDINAMINE

Base Information

• Chemical Name: N,N,4-TRIMETHYL-2-PYRIDINAMINE
• CAS No.: 20173-72-2
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.197
• Hs Code.: 2933399090
• Mol file: 20173-72-2.mol

Synonyms:2-dimethylamino-4-methylpyridine;N,N-dimethyl-2-amino-4-picoline;2-Dimethylamino-4-methyl-pyridin;

Chemical Property of N,N,4-TRIMETHYL-2-PYRIDINAMINE

Chemical Property:

• Vapor Pressure: 0.0891mmHg at 25°C
• Boiling Point: 224.9°C at 760 mmHg
• Flash Point: 89.8°C
• PSA: 16.13000
• Density: 0.994g/cm³
• LogP: 1.45600
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

N,N,4-Trimethylpyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N,4-TRIMETHYL-2-PYRIDINAMINE

There total 6 articles about N,N,4-TRIMETHYL-2-PYRIDINAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-Amino-4-methylpyridine (695-34-1) + acetic acid (64-19-7,77671-22-8) → 2-(N,N-dimethylamino)-4-methylpyridine (20173-72-2)

Guidance literature:

With formaldehyd; sodium cyanoborohydride; In water; acetonitrile; at 0 - 20 ℃; for 168h;

Reference yield: 80.0%

2-Amino-4-methylpyridine (695-34-1) + methyl iodide (74-88-4) → 2-(N,N-dimethylamino)-4-methylpyridine (20173-72-2)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere;

DOI:10.1002/asia.201300930

Reference yield: 57.0%

2-fluoro-4-methylpyridine (461-87-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-(N,N-dimethylamino)-4-methylpyridine (20173-72-2)

Guidance literature:

With potassium hydroxide; In neat (no solvent); at 100 ℃; for 24h; Sealed tube;

DOI:10.1021/acs.joc.8b02588

upstream raw materials:

2-Amino-4-methylpyridine

formaldehyd

acetic acid

methyl iodide

Downstream raw materials:

3-[6-(dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[2,3-a]pyrimidine-7-amine

2-dimethylamino-4-methyl-5-formylpyridine

2-dimethylamino-4-methyl-5-(cyanomethyl)pyridine

Refernces

• 1、 Yang, Chu,Zhang, Feng,Deng, Guo-Jun,Gong, Hang. "Amination of Aromatic Halides and Exploration of the Reactivity Sequence of Aromatic Halides". . p. 181 - 190. Retrieved 2019/01/10.
• 2、 -. "PYRAZOLO [1,5-ALPHA] PYRIMIDINYL DERIVATIVES USEFUL AS CORTICOTROPIN-RELEASING FACTOR (CRF) RECEPTOR ANTAGONISTS". Page/Page column 38-39. . Retrieved 2008/06/13.