butyl 3-(4-fluorophenyl)propionate

Base Information

• Chemical Name: butyl 3-(4-fluorophenyl)propionate
• CAS No.: 1449127-55-2
• Molecular Formula: C₁₃H₁₃FO₂
• Molecular Weight: 220.243
• Mol file: 1449127-55-2.mol

Synonyms:butyl 3-(4-fluorophenyl)propionate

Chemical Property of butyl 3-(4-fluorophenyl)propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of butyl 3-(4-fluorophenyl)propionate

There total 2 articles about butyl 3-(4-fluorophenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-ethynyl-4-fluorobenzene (766-98-3) + 1-iodo-butane (542-69-8) + carbon dioxide (124-38-9,18923-20-1) → butyl 3-(4-fluorophenyl)propionate (1449127-55-2)

Guidance literature:

1-ethynyl-4-fluorobenzene; carbon dioxide; With caesium carbonate; In dimethyl sulfoxide; at 80 ℃; for 4h; under 760.051 Torr; Inert atmosphere; Glovebox;

1-iodo-butane; In dimethyl sulfoxide; at 40 ℃; for 1h; Inert atmosphere; Glovebox;

DOI:10.1002/hlca.201900258

Reference yield: 82.0%

1-bromo-butane (109-65-9) + 1-ethynyl-4-fluorobenzene (766-98-3) + carbon dioxide (124-38-9,18923-20-1) → butyl 3-(4-fluorophenyl)propionate (1449127-55-2)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 16h; under 1520.1 Torr; Reagent/catalyst;

DOI:10.1134/S1070428019120017

upstream raw materials:

1-ethynyl-4-fluorobenzene

1-iodo-butane

carbon dioxide

1-bromo-butane