2-(Aminomethyl)pyridin-3-ol

Base Information

• Chemical Name: 2-(Aminomethyl)pyridin-3-ol
• CAS No.: 194665-89-9
• Molecular Formula: C6H8 N2 O
• Molecular Weight: 124.14
• Hs Code.: 2933399090
• European Community (EC) Number: 851-777-5
• DSSTox Substance ID: DTXSID20442963
• Wikidata: Q82260599
• Mol file: 194665-89-9.mol

Synonyms:2-(aminomethyl)pyridin-3-ol;194665-89-9;2-Aminomethyl-pyridin-3-ol;3-Pyridinol,2-(aminomethyl)-(9CI);3-PYRIDINOL, 2-(AMINOMETHYL)-;2-aminomethylpyridin-3-ol;SCHEMBL4212829;DTXSID20442963;MFCD01217253;AKOS006278956;MB01728;AS-61284;2-(AMINOMETHYL)-3-HYDROXYPYRIDINE;CS-0214767;C73700;EN300-191576;A880184;F2147-1531;Z1198156472

Chemical Property of 2-(Aminomethyl)pyridin-3-ol

Chemical Property:

• PSA: 59.14000
• LogP: 0.94620
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 124.063662883
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

97% ^*data from raw suppliers

2-(aminomethyl)pyridin-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)CN)O

Technology Process of 2-(Aminomethyl)pyridin-3-ol

There total 2 articles about 2-(Aminomethyl)pyridin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

3-hydroxypyridine-2-carbonitrile (932-35-4) → 2-aminomethyl-3-hydroxypyridine (194665-89-9)

Guidance literature:

With ammonia; hydrogen; palladium on activated charcoal; In ethanol; at 45 ℃; for 6h; under 2280 Torr;

DOI:10.1080/00397919708004997

Reference yield:

3-hydroxypyridine N-oxide (6602-28-4) → 2-aminomethyl-3-hydroxypyridine (194665-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / triethylamine / acetonitrile / 8 h / 100 - 110 °C

2: 50 percent / H₂; NH₃ / palladium on charcoal / ethanol / 6 h / 45 °C / 2280 Torr

With ammonia; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; acetonitrile; 1: Substitution / 2: Catalytic hydrogenation;

DOI:10.1080/00397919708004997

Reference yield: 40.0%

4-chloro-3-methylphenyl dichlorophosphate (775-13-3) + 2-aminomethyl-3-hydroxypyridine (194665-89-9) → 2-(4-chloro-3-methyl-phenoxy)-3,4-dihydro-1-oxa-3,5-diaza-2-phospha-naphthalene 2-oxide

Guidance literature:

With triethylamine; In tetrahydrofuran; toluene; at 20 - 60 ℃;

DOI:10.1080/00397919708004997

upstream raw materials:

3-hydroxypyridine-2-carbonitrile

3-hydroxypyridine N-oxide