2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Base Information

• Chemical Name: 2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine
• CAS No.: 151385-65-8
• Molecular Formula: C₂₆H₂₅FN₄O₂
• Molecular Weight: 444.509
• Mol file: 151385-65-8.mol

Synonyms:2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Chemical Property of 2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

There total 6 articles about 2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2-(phenylhydrazono)-propanedioyl dichloride (19288-90-5) + 2-fluoro-2'-(3-methylbut-1-yl)aminodiphenylamine (151385-64-7) → 2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine (151385-65-8)

Guidance literature:

In tetrahydrofuran; at 50 ℃; for 2h;

DOI:10.1002/ardp.19973301107

Reference yield:

N-(2-fluorophenyl)benzene-1,2-diamine (28898-03-5) → 2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine (151385-65-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / NaI / dimethylformamide / 8 h / 120 °C

2: 57 percent / tetrahydrofuran / 3 h / 50 °C

With sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Alkylation / 2: Acylation;

DOI:10.1021/jm990967h

Reference yield:

i-pentyl bromide (107-82-4) → 2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine (151385-65-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / NaI / dimethylformamide / 8 h / 120 °C

2: 57 percent / tetrahydrofuran / 3 h / 50 °C

With sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Alkylation / 2: Acylation;

DOI:10.1021/jm990967h

upstream raw materials:

2-(phenylhydrazono)-propanedioyl dichloride

2-fluoro-2'-(3-methylbut-1-yl)aminodiphenylamine

N-(2-fluorophenyl)benzene-1,2-diamine

i-pentyl bromide

Downstream raw materials:

2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

2,4-dioxo-5-N-(2-fluorophenyl)-3-isocyanato-1-N-(3-methylbut-1-yl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

3-amino-2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine