2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

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Chemical Name:2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine
CAS No.:151620-15-4
Molecular Formula:C₂₇H₂₆FN₃O₄
Molecular Weight:475.52
Hs Code.:

Synonyms:2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

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Chemical Property of 2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

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Technology Process of 2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

There total 9 articles about 2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1885-14-9
phenyl chloroformate

: 151386-23-1,151620-60-9,307967-13-1
3-amino-2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

: 151620-15-4
2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Guidance literature:: With pyridine; In dichloromethane; at 23 ℃; for 0.5h;
DOI:10.1002/ardp.19973301107

Reference yield:

: 28898-03-5
N-(2-fluorophenyl)benzene-1,2-diamine

: 151620-15-4
2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / NaI / dimethylformamide / 8 h / 120 °C

2: 57 percent / tetrahydrofuran / 3 h / 50 °C

3: 2.8 g / Zn; AcOH / 3 h / 23 °C

4: 74 percent / pyridine / CH₂Cl₂ / 0.5 h / 23 °C

With pyridine; acetic acid; sodium iodide; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Alkylation / 2: Acylation / 3: Reduction / 4: Acylation;
DOI:10.1021/jm990967h

Reference yield:

: 151385-65-8
2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

: 151620-15-4
2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 2.8 g / Zn; AcOH / 3 h / 23 °C

2: 74 percent / pyridine / CH₂Cl₂ / 0.5 h / 23 °C

With pyridine; acetic acid; zinc; In dichloromethane; 1: Reduction / 2: Acylation;
DOI:10.1021/jm990967h