N-(2-bromopyridin-4-yl)-2,6-dichloro-4-(1H-pyrazol-4-yl)benzamide

Base Information

Chemical Name:N-(2-bromopyridin-4-yl)-2,6-dichloro-4-(1H-pyrazol-4-yl)benzamide
CAS No.:1438897-31-4
Molecular Formula:C₁₅H₉BrCl₂N₄O
Molecular Weight:412.073
Hs Code.:

Synonyms:N-(2-bromopyridin-4-yl)-2,6-dichloro-4-(1H-pyrazol-4-yl)benzamide

Suppliers and Price of N-(2-bromopyridin-4-yl)-2,6-dichloro-4-(1H-pyrazol-4-yl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(2-bromopyridin-4-yl)-2,6-dichloro-4-(1H-pyrazol-4-yl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(2-bromopyridin-4-yl)-2,6-dichloro-4-(1H-pyrazol-4-yl)benzamide

There total 9 articles about N-(2-bromopyridin-4-yl)-2,6-dichloro-4-(1H-pyrazol-4-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 763120-58-7
1H-pyrazole-4-boronic acid

: 1258298-17-7
N-(2-bromopyridin-4-yl)-2,6-dichloro-4-iodobenzamide

: 1438897-31-4
N-(2-bromopyridin-4-yl)-2,6-dichloro-4-(1H-pyrazol-4-yl)benzamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In water; acetonitrile; at 160 ℃; for 1h; Microwave irradiation;
DOI:10.1021/jm400266t

Reference yield:

: 1098619-84-1
trifluoro-methanesulfonic acid 4-tert-butoxycarbonylamino-2,6-dichloro-phenyl ester

: 1438897-31-4
N-(2-bromopyridin-4-yl)-2,6-dichloro-4-(1H-pyrazol-4-yl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: palladium diacetate; triethylamine; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 7600.51 Torr

2.1: sulfuric acid / ethyl acetate / 2 h / 20 °C

3.1: hydrogenchloride; sodium nitrite / water / 0.5 h / -5 - 0 °C

3.2: 20 °C

4.1: pyridine; lithium iodide / water / 30 h / 130 °C

5.1: thionyl chloride / Reflux; Inert atmosphere

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C / Inert atmosphere

6.2: 12 h / 0 - 25 °C / Inert atmosphere

7.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / water; acetonitrile / 1 h / 160 °C / Microwave irradiation

With pyridine; hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; thionyl chloride; sulfuric acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; sodium hydride; caesium carbonate; triethylamine; lithium iodide; sodium nitrite; In water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/jm400266t

Reference yield:

: 232275-49-9
methyl 4-amino-2,6-dichlorobenzoate

: 1438897-31-4
N-(2-bromopyridin-4-yl)-2,6-dichloro-4-(1H-pyrazol-4-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / -5 - 0 °C

1.2: 20 °C

2.1: pyridine; lithium iodide / water / 30 h / 130 °C

3.1: thionyl chloride / Reflux; Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C / Inert atmosphere

4.2: 12 h / 0 - 25 °C / Inert atmosphere

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / water; acetonitrile / 1 h / 160 °C / Microwave irradiation

With pyridine; hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; thionyl chloride; sodium hydride; caesium carbonate; lithium iodide; sodium nitrite; In water; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/jm400266t