(S,S)-N-BENZYL-3,4-TRANS-DIAMINOPYRROLIDINE

Base Information

• Chemical Name: (S,S)-N-BENZYL-3,4-TRANS-DIAMINOPYRROLIDINE
• CAS No.: 193352-75-9
• Molecular Formula: C11H17 N3
• Molecular Weight: 191.276
• Hs Code.: 2933990090
• Mol file: 193352-75-9.mol

Synonyms:3,4-Pyrrolidinediamine,1-(phenylmethyl)-, (3S-trans)- (9CI)

Chemical Property of (S,S)-N-BENZYL-3,4-TRANS-DIAMINOPYRROLIDINE

Chemical Property:

• Refractive Index: 1.5440 to 1.5480
• Boiling Point: 296.8±40.0 °C(Predicted)
• PKA: 9.65±0.40(Predicted)
• Flash Point: 132°C
• PSA: 55.28000
• Density: 1.104±0.06 g/cm3(Predicted)
• LogP: 1.49530

Purity/Quality:

98%,99%, ^*data from raw suppliers

(3S,4S)-3,4-Diamino-1-benzylpyrrolidine ≥90.0% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S,S)-N-BENZYL-3,4-TRANS-DIAMINOPYRROLIDINE

There total 7 articles about (S,S)-N-BENZYL-3,4-TRANS-DIAMINOPYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,4-Diazido-1-benzylpyrrolidine (288313-99-5) → (3S,4S)-1-benzyl-pyrrolidine-3,4-diamine (193352-75-9,246149-02-0)

Guidance literature:

With hydrogen; MCM-silylamine Pd(II); In methanol; at 20 ℃; for 2h;

DOI:10.1055/s-1999-2846

Reference yield:

(3R,4R)-1-benzyl-3,4-pyrrolidinediol (163439-82-5,330152-66-4) → (3S,4S)-1-benzyl-pyrrolidine-3,4-diamine (193352-75-9,246149-02-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / HN₃; DEAD; PPh₃

2: LiAlH₄ / tetrahydrofuran / 0.5 h / Heating

With lithium aluminium tetrahydride; tris-(2-chloro-ethyl)-amine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1: Substitution / 2: Reduction;

DOI:10.1021/jo991628z

Reference yield:

(3S,4S)-1-benzyl-3,4-pyrrolidinediyl bis(methanesulfonate) (104351-40-8,1227269-36-4) → (3S,4S)-1-benzyl-pyrrolidine-3,4-diamine (193352-75-9,246149-02-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaN₃ / dimethylformamide / 4 h / 100 °C

2: H₂ / Pd/C / dimethylformamide / 12 h / 3000.24 Torr

With sodium azide; hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide;

DOI:10.1002/1099-0682(200109)2001:10<2525::AID-EJIC2525>3.0.CO;2-Z

upstream raw materials:

3,4-Diazido-1-benzylpyrrolidine

(3S,4S)-1-benzyl-3,4-pyrrolidinediyl bis(methanesulfonate)

(3R,4R)-1-benzyl-3,4-pyrrolidinediol

(3S,4S)-1-N-benzyl-3,4-dihydroxypyrrolidine-2,6-dione

Downstream raw materials:

N-benzyl-3,4-di(Boc-amino)pyrrolidine