Technology Process of 5,8-dimethoxy-4-(2-nitrophenyl)-7-quinolinecarboxylic acid
There total 21 articles about 5,8-dimethoxy-4-(2-nitrophenyl)-7-quinolinecarboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hydroxide monohydrate;
In
tetrahydrofuran; methanol; water;
at 20 ℃;
for 10h;
Inert atmosphere;
DOI:10.3390/md12094833
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 52 percent / polyphosphoric acid / 5 h / 75 °C
2.1: 70 percent / triethylamine / 0.5 h / -20 °C
3.1: 87 percent / formic acid; triethylamine / palladium(II) acetate; 1,1'-bis(diphenylphosphino)ferrocene / dimethylformamide / 2 h / 0 - 60 °C
4.1: glacial acetic acid; sulfuric acid / H2O / 2 h / Heating
5.1: sodium nitrite / H2O / 0 - 5 °C
5.2: 265 mg / H2O / 1.25 h / 45 - 50 °C
6.1: sulfuric acid / 3.5 h / 60 - 70 °C
7.1: 43 mg / H2O / 2 h / 120 °C
With
formic acid; PPA; sulfuric acid; water; acetic acid; triethylamine; sodium nitrite;
1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate;
In
water; N,N-dimethyl-formamide;
1.1: Knorr cyclization / 5.2: Sandmeyer reaction;
DOI:10.1021/jo7017813
