5,10-dimethoxy-8-methyl-4-(2-nitrophenyl)-pyrido-[4,3-g]-quinolin-9(8H)-one

Base Information

Chemical Name:5,10-dimethoxy-8-methyl-4-(2-nitrophenyl)-pyrido-[4,3-g]-quinolin-9(8H)-one
CAS No.:957110-24-6
Molecular Formula:C₂₁H₁₇N₃O₅
Molecular Weight:391.383
Hs Code.:

Synonyms:5,10-dimethoxy-8-methyl-4-(2-nitrophenyl)-pyrido-[4,3-g]-quinolin-9(8H)-one

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Chemical Property of 5,10-dimethoxy-8-methyl-4-(2-nitrophenyl)-pyrido-[4,3-g]-quinolin-9(8H)-one

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Technology Process of 5,10-dimethoxy-8-methyl-4-(2-nitrophenyl)-pyrido-[4,3-g]-quinolin-9(8H)-one

There total 15 articles about 5,10-dimethoxy-8-methyl-4-(2-nitrophenyl)-pyrido-[4,3-g]-quinolin-9(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 957110-22-4
7-[N-(2,2-dimethoxyethyl)-N-methyl]-carboxamide-5,8-dimethoxy-4-(2-nitrophenyl)quinoline

: 957110-24-6
5,10-dimethoxy-8-methyl-4-(2-nitrophenyl)-pyrido-[4,3-g]-quinolin-9(8H)-one

Guidance literature:: 7-[N-(2,2-dimethoxyethyl)-N-methyl]-carboxamide-5,8-dimethoxy-4-(2-nitrophenyl)quinoline; With sulfuric acid; at 20 ℃; for 4h;

at 150 ℃; for 0.166667h; Further stages.;
DOI:10.1021/jo7017813

Reference yield:

: 957110-12-2
3-acetamido-2,5-dimethoxy-2-(nitrobenzoyl)-acetanilide

: 957110-24-6
5,10-dimethoxy-8-methyl-4-(2-nitrophenyl)-pyrido-[4,3-g]-quinolin-9(8H)-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: 52 percent / polyphosphoric acid / 5 h / 75 °C

2.1: 70 percent / triethylamine / 0.5 h / -20 °C

3.1: 87 percent / formic acid; triethylamine / palladium(II) acetate; 1,1'-bis(diphenylphosphino)ferrocene / dimethylformamide / 2 h / 0 - 60 °C

4.1: glacial acetic acid; sulfuric acid / H₂O / 2 h / Heating

5.1: sodium nitrite / H₂O / 0 - 5 °C

5.2: 265 mg / H₂O / 1.25 h / 45 - 50 °C

6.1: sulfuric acid / 3.5 h / 60 - 70 °C

7.1: 43 mg / H₂O / 2 h / 120 °C

8.1: 87 percent / EDC*HCl / CH₂Cl₂ / 15 h / 20 °C

9.1: sulfuric acid / 4 h / 20 °C

9.2: 43 percent / 0.17 h / 150 °C

With formic acid; PPA; sulfuric acid; water; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In dichloromethane; water; N,N-dimethyl-formamide; 1.1: Knorr cyclization / 5.2: Sandmeyer reaction;
DOI:10.1021/jo7017813

Reference yield:

: 957110-13-3
7-acetamido-5,8-dimethoxy-4-(2-nitrophenyl)-2(1H)-quinolinone

: 957110-24-6
5,10-dimethoxy-8-methyl-4-(2-nitrophenyl)-pyrido-[4,3-g]-quinolin-9(8H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: 70 percent / triethylamine / 0.5 h / -20 °C

2.1: 87 percent / formic acid; triethylamine / palladium(II) acetate; 1,1'-bis(diphenylphosphino)ferrocene / dimethylformamide / 2 h / 0 - 60 °C

3.1: glacial acetic acid; sulfuric acid / H₂O / 2 h / Heating

4.1: sodium nitrite / H₂O / 0 - 5 °C

4.2: 265 mg / H₂O / 1.25 h / 45 - 50 °C

5.1: sulfuric acid / 3.5 h / 60 - 70 °C

6.1: 43 mg / H₂O / 2 h / 120 °C

7.1: 87 percent / EDC*HCl / CH₂Cl₂ / 15 h / 20 °C

8.1: sulfuric acid / 4 h / 20 °C

8.2: 43 percent / 0.17 h / 150 °C

With formic acid; sulfuric acid; water; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In dichloromethane; water; N,N-dimethyl-formamide; 4.2: Sandmeyer reaction;
DOI:10.1021/jo7017813