{1-[(S)-1-amino-1-(2-fluoro-5-nitro-phenyl)-ethyl]-cyclopropyl}-methanol

Base Information

• Chemical Name: {1-[(S)-1-amino-1-(2-fluoro-5-nitro-phenyl)-ethyl]-cyclopropyl}-methanol
• CAS No.: 1075231-42-3
• Molecular Formula: C₁₂H₁₅FN₂O₃
• Molecular Weight: 254.261
• Mol file: 1075231-42-3.mol

Synonyms:{1-[(S)-1-amino-1-(2-fluoro-5-nitro-phenyl)-ethyl]-cyclopropyl}-methanol

Chemical Property of {1-[(S)-1-amino-1-(2-fluoro-5-nitro-phenyl)-ethyl]-cyclopropyl}-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {1-[(S)-1-amino-1-(2-fluoro-5-nitro-phenyl)-ethyl]-cyclopropyl}-methanol

There total 4 articles about {1-[(S)-1-amino-1-(2-fluoro-5-nitro-phenyl)-ethyl]-cyclopropyl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[(S)-1-amino-1-(2-fluoro-5-nitrophenyl)ethyl]cyclopropanecarboxylic acid hydrochloride salt (1075231-41-2) → {1-[(S)-1-amino-1-(2-fluoro-5-nitro-phenyl)-ethyl]-cyclopropyl}-methanol (1075231-42-3)

Guidance literature:

1-[(S)-1-amino-1-(2-fluoro-5-nitrophenyl)ethyl]cyclopropanecarboxylic acid hydrochloride salt; With borane-THF; In tetrahydrofuran; at 20 ℃; Cooling with ice;

With water; sodium hydrogencarbonate; In tetrahydrofuran; Cooling with ice;

Reference yield:

1-(2-fluoro-5-nitrophenyl)ethanone (79110-05-7) → {1-[(S)-1-amino-1-(2-fluoro-5-nitro-phenyl)-ethyl]-cyclopropyl}-methanol (1075231-42-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 5 h / Reflux

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -78 °C

2.2: 4 h

3.1: hydrogenchloride / ethyl acetate / 5.5 h / 65 °C / Sealed tube

4.1: borane-THF / tetrahydrofuran / 3 h / 0 °C

With hydrogenchloride; titanium(IV) tetraethanolate; n-butyllithium; borane-THF; diisopropylamine; In tetrahydrofuran; hexane; ethyl acetate;

Reference yield:

(R)-2-methylpropane-2-sulfinic acid [1-(2-fluoro-5-nitrophenyl)-(E)-ethylidene]amide (1075230-62-4) → {1-[(S)-1-amino-1-(2-fluoro-5-nitro-phenyl)-ethyl]-cyclopropyl}-methanol (1075231-42-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -78 °C

1.2: 4 h

2.1: hydrogenchloride / ethyl acetate / 5.5 h / 65 °C / Sealed tube

3.1: borane-THF / tetrahydrofuran / 3 h / 0 °C

With hydrogenchloride; n-butyllithium; borane-THF; diisopropylamine; In tetrahydrofuran; hexane; ethyl acetate;

upstream raw materials:

1-[(S)-1-amino-1-(2-fluoro-5-nitrophenyl)ethyl]cyclopropanecarboxylic acid hydrochloride salt

1-(2-fluoro-5-nitrophenyl)ethanone

1-[(S)-1-(2-fluoro-5-nitro-phenyl)-1-((R)-2-methyl-propane-2-sulfinylamino)-ethyl]-cyclopropanecarboxylic acid tert-butyl ester

(R)-2-methylpropane-2-sulfinic acid [1-(2-fluoro-5-nitrophenyl)-(E)-ethylidene]amide

Downstream raw materials:

C₂₀H₂₀FN₃O₄S

(S)-8-(5-amino-2-fluoro-phenyl)-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-6-ylamine

5-chloro-pyridine-2-carboxylic acid [3-((S)-6-amino-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-8-yl)-4-fluoro-phenyl]-amide

(S)-8-(2-fluoro-5-nitro-phenyl)-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-6-ylamine