3-chloro-5-((4-methoxy-2-methylphenyl)ethynyl)picolinonitrile

Base Information

• Chemical Name: 3-chloro-5-((4-methoxy-2-methylphenyl)ethynyl)picolinonitrile
• CAS No.: 1186637-69-3
• Molecular Formula: C₁₆H₁₁ClN₂O
• Molecular Weight: 282.729
• Mol file: 1186637-69-3.mol

Synonyms:3-chloro-5-((4-methoxy-2-methylphenyl)ethynyl)picolinonitrile

Chemical Property of 3-chloro-5-((4-methoxy-2-methylphenyl)ethynyl)picolinonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-chloro-5-((4-methoxy-2-methylphenyl)ethynyl)picolinonitrile

There total 1 articles about 3-chloro-5-((4-methoxy-2-methylphenyl)ethynyl)picolinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Cyano-3,5-dichloropyridine (85331-33-5) + 1-ethynyl-4-methoxy-2-methylbenzene (74331-69-4) → 3-chloro-5-((4-methoxy-2-methylphenyl)ethynyl)picolinonitrile (1186637-69-3)

Guidance literature:

With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; at 60 ℃;

Reference yield:

3-chloro-5-((4-methoxy-2-methylphenyl)ethynyl)picolinonitrile (1186637-69-3) + tert-butyl 5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate (1150561-75-3) → 2-((4-methoxy-2-methylphenyl)ethynyl)-8-methylbenzo[f][1,7]naphthyridin-5-amine (1186637-70-6)

Guidance literature:

With potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In water; butan-1-ol; at 100 ℃; Inert atmosphere;

Reference yield:

3-chloro-5-((4-methoxy-2-methylphenyl)ethynyl)picolinonitrile (1186637-69-3) + tert-butyl 5-((tert-butyldimethylsilyloxy)methyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate (1186638-29-8) → 8-((tert-butyldimethylsilyloxy)methyl)-2-((4-methoxy-2-methylphenyl)ethynyl)benzo[f][1,7]naphthyridin-5-amine (1268526-86-8)

Guidance literature:

With potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In water; butan-1-ol; at 100 ℃; Inert atmosphere;

upstream raw materials:

2-Cyano-3,5-dichloropyridine

1-ethynyl-4-methoxy-2-methylbenzene

Downstream raw materials:

2-((4-methoxy-2-methylphenyl)ethynyl)-8-methylbenzo[f][1,7]naphthyridin-5-amine

2-(4-methoxy-2-methylphenethyl)-8-methylbenzo[f][1,7]naphthyridin-5-amine

4-(2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl)-3-methylphenol

5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f]-[1,7]naphthyridine-8-carbaldehyde