Technology Process of 3-[[2-fluoro-5-(3-fluorophenyl)-3-methylphenyl]methylamino]-2,4-dimethylphenol
There total 10 articles about 3-[[2-fluoro-5-(3-fluorophenyl)-3-methylphenyl]methylamino]-2,4-dimethylphenol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
borane-THF;
In
tetrahydrofuran;
at 60 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: nitric acid; acetic acid; sulfuric acid / 1 h / 0 - 20 °C
2.1: palladium 10% on activated carbon; hydrogen / ethanol; methanol; acetic acid / 36 h / 20 °C
3.1: sodium nitrite; sulfuric acid / water / 0.5 h / 0 °C
3.2: 2 h / 100 °C
4.1: dmap; triethylamine / N,N-dimethyl-formamide / 50 °C
5.1: hydrazine hydrate / tert-butyl alcohol / 110 °C / Inert atmosphere
6.1: trifluoroacetic acid / dichloromethane / 20 °C
7.1: sodium hydrogencarbonate / tetrahydrofuran / 1 h / 0 - 20 °C
8.1: borane-THF / tetrahydrofuran / 60 °C / Inert atmosphere
With
dmap; borane-THF; sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; sodium hydrogencarbonate; hydrazine hydrate; acetic acid; triethylamine; trifluoroacetic acid; sodium nitrite;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: palladium 10% on activated carbon; hydrogen / ethanol; methanol; acetic acid / 36 h / 20 °C
2.1: sodium nitrite; sulfuric acid / water / 0.5 h / 0 °C
2.2: 2 h / 100 °C
3.1: dmap; triethylamine / N,N-dimethyl-formamide / 50 °C
4.1: hydrazine hydrate / tert-butyl alcohol / 110 °C / Inert atmosphere
5.1: trifluoroacetic acid / dichloromethane / 20 °C
6.1: sodium hydrogencarbonate / tetrahydrofuran / 1 h / 0 - 20 °C
7.1: borane-THF / tetrahydrofuran / 60 °C / Inert atmosphere
With
dmap; borane-THF; sulfuric acid; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; hydrazine hydrate; triethylamine; trifluoroacetic acid; sodium nitrite;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol;
