5,11-Dihydro-5-[4-[2-(1-piperidinyl)ethoxy]phenyl][1]benzopyrano[4,3-c][1]benzopyran-2,8-diol

Base Information

Chemical Name:5,11-Dihydro-5-[4-[2-(1-piperidinyl)ethoxy]phenyl][1]benzopyrano[4,3-c][1]benzopyran-2,8-diol
CAS No.:554430-98-7
Molecular Formula:C₂₉H₂₉NO₅
Molecular Weight:471.553
Hs Code.:
DSSTox Substance ID:DTXSID901119170
ChEMBL ID:CHEMBL379415

Synonyms:CHEMBL379415;SCHEMBL5110067;SCHEMBL14277799;DTXSID901119170;5,11-Dihydro-5-[4-[2-(1-piperidinyl)ethoxy]phenyl][1]benzopyrano[4,3-c][1]benzopyran-2,8-diol;554430-98-7

Suppliers and Price of 5,11-Dihydro-5-[4-[2-(1-piperidinyl)ethoxy]phenyl][1]benzopyrano[4,3-c][1]benzopyran-2,8-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5,11-Dihydro-5-[4-[2-(1-piperidinyl)ethoxy]phenyl][1]benzopyrano[4,3-c][1]benzopyran-2,8-diol

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:471.20457303
Heavy Atom Count:35
Complexity:743

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCN(CC1)CCOC2=CC=C(C=C2)C3C4=C(COC5=C4C=CC(=C5)O)C6=C(O3)C=C(C=C6)O

Technology Process of 5,11-Dihydro-5-[4-[2-(1-piperidinyl)ethoxy]phenyl][1]benzopyrano[4,3-c][1]benzopyran-2,8-diol

There total 5 articles about 5,11-Dihydro-5-[4-[2-(1-piperidinyl)ethoxy]phenyl][1]benzopyrano[4,3-c][1]benzopyran-2,8-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 554430-39-6
2,8-bis(tert-butyldimethylsilyloxy)-5-[4-(2-(piperidin-1-yl)ethoxy)phenyl]-5,11-dihydrochromeno[4,3-c]chromene

: 554430-98-7
5-[4-(2-(piperidin-1-yl)ethoxy)phenyl]-5,11-dihydrochromeno[4,3-c]-chromene-2,8-diol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.416667h;
DOI:10.1021/op700020f

Reference yield:

: 554430-12-5
2-(4-(hydroxy-(4-(2-(piperidin-1-yl)ethoxy)phenyl)methyl))-7-(tert-butyldimethylsilyloxy-2H-chromen-3-yl)-5-(tertbutyldimethylsilyloxy)phenol

: 554430-98-7
5-[4-(2-(piperidin-1-yl)ethoxy)phenyl]-5,11-dihydrochromeno[4,3-c]-chromene-2,8-diol

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl / toluene / 0.5 h / 20 °C

2: tetra-n-butylammonium fluoride / tetrahydrofuran / 3 h

With hydrogenchloride; tetrabutyl ammonium fluoride; In tetrahydrofuran; toluene;
DOI:10.1021/jm060353u

Reference yield:

: 554430-87-4
2,8-bis(tert-butyl-dimethyl-silyloxy)-11H-chromeno[4,3-c]chromen-5-one

: 554430-98-7
5-[4-(2-(piperidin-1-yl)ethoxy)phenyl]-5,11-dihydrochromeno[4,3-c]-chromene-2,8-diol

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminum hydride / toluene / 5 h / -78 °C

2.1: n-BuLi / tetrahydrofuran; pentane / 1 h / -78 °C

2.2: tetrahydrofuran; pentane / 1 h / -78 °C

3.1: aq. HCl / toluene / 0.5 h / 20 °C

4.1: tetra-n-butylammonium fluoride / tetrahydrofuran / 3 h

With hydrogenchloride; n-butyllithium; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; In tetrahydrofuran; toluene; pentane;
DOI:10.1021/jm060353u