1-{3-[4,4-bis(4-fluorophenyl)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl]propyl}-4-piperidinecarboxylic acid

Base Information

Chemical Name:1-{3-[4,4-bis(4-fluorophenyl)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl]propyl}-4-piperidinecarboxylic acid
CAS No.:721952-75-6
Molecular Formula:C₂₅H₂₇F₂N₃O₃
Molecular Weight:455.504
Hs Code.:

Synonyms:1-{3-[4,4-bis(4-fluorophenyl)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl]propyl}-4-piperidinecarboxylic acid

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Chemical Property of 1-{3-[4,4-bis(4-fluorophenyl)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl]propyl}-4-piperidinecarboxylic acid

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Technology Process of 1-{3-[4,4-bis(4-fluorophenyl)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl]propyl}-4-piperidinecarboxylic acid

There total 1 articles about 1-{3-[4,4-bis(4-fluorophenyl)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl]propyl}-4-piperidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 721952-74-5
ethyl 1-{3-[4,4-bis(4-fluorophenyl)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl]propyl}-4-piperidinecarboxylate

: 721952-75-6
1-{3-[4,4-bis(4-fluorophenyl)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl]propyl}-4-piperidinecarboxylic acid

Guidance literature:: ethyl 1-{3-[4,4-bis(4-fluorophenyl)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl]propyl}-4-piperidinecarboxylate; With potassium hydroxide; water; In tetrahydrofuran; methanol; at 20 - 60 ℃; for 6h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; ethyl acetate; pH=4;

Reference yield: 60.0%

: 721952-75-6
1-{3-[4,4-bis(4-fluorophenyl)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl]propyl}-4-piperidinecarboxylic acid

: 6148-64-7
ethyl potassium malonate

: 721952-78-9
3-(1-{3-[4,4-bis(4-fluorophenyl)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl]propyl}-4-piperidinyl)-3-oxopropanoate

Guidance literature:: ethyl potassium malonate; With magnesium chloride; In tetrahydrofuran; at 65 ℃; for 4h;

1-{3-[4,4-bis(4-fluorophenyl)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl]propyl}-4-piperidinecarboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 12h;