2,6-Dichloro-benzoic acid (2R,3S)-3-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-ethoxycarbonyl-2-hydroxy-butyl ester

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Chemical Name:2,6-Dichloro-benzoic acid (2R,3S)-3-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-ethoxycarbonyl-2-hydroxy-butyl ester
CAS No.:161401-77-0
Molecular Formula:C₃₀H₃₇Cl₂N₃O₉
Molecular Weight:654.544
Hs Code.:

2,6-Dichloro-benzoic acid (2R,3S)-3-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-ethoxycarbonyl-2-hydroxy-butyl ester

Synonyms:2,6-Dichloro-benzoic acid (2R,3S)-3-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-ethoxycarbonyl-2-hydroxy-butyl ester

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Chemical Property of 2,6-Dichloro-benzoic acid (2R,3S)-3-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-ethoxycarbonyl-2-hydroxy-butyl ester

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Technology Process of 2,6-Dichloro-benzoic acid (2R,3S)-3-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-ethoxycarbonyl-2-hydroxy-butyl ester

There total 5 articles about 2,6-Dichloro-benzoic acid (2R,3S)-3-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-ethoxycarbonyl-2-hydroxy-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 4659-45-4
2,6-Dichlorobenzoyl chloride

: 161401-76-9
(3S,4R)-3-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4,5-dihydroxy-pentanoic acid ethyl ester

: 161401-77-0
2,6-Dichloro-benzoic acid (2R,3S)-3-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-ethoxycarbonyl-2-hydroxy-butyl ester

Guidance literature:: With dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In pyridine; for 48h;
DOI:10.1016/0040-4039(94)88361-0

Reference yield:

: 36326-38-2,64520-58-7,91057-97-5,91926-90-8,104321-63-3,124818-64-0,128525-67-7,128525-69-9,104321-62-2,917877-01-1
ethyl (E)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]acrylate

: 161401-77-0
2,6-Dichloro-benzoic acid (2R,3S)-3-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-ethoxycarbonyl-2-hydroxy-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) benzylamine; 2.) hydrogen / 2.) Pd/C / 1.) -20 deg C, 40 h; 2.) EtOH

2: 66 percent / HOBt, EDCl / tetrahydrofuran / 0 deg C to r.t, 12 h

3: 73 percent / Montmorillonite K₁₀ / ethanol; H₂O / 2.75 h / 75 °C

4: 93 percent / DMAP, DMPU / pyridine / 48 h

With dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; Montmorillonite K₁₀; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzylamine; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethanol; water;
DOI:10.1016/0040-4039(94)88361-0

Reference yield:

: 17445-33-9,17445-34-0,24787-89-1,121428-71-5
(S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanamido)propanoic acid

: 161401-77-0
2,6-Dichloro-benzoic acid (2R,3S)-3-[(S)-2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-ethoxycarbonyl-2-hydroxy-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / HOBt, EDCl / tetrahydrofuran / 0 deg C to r.t, 12 h

2: 73 percent / Montmorillonite K₁₀ / ethanol; H₂O / 2.75 h / 75 °C

3: 93 percent / DMAP, DMPU / pyridine / 48 h

With dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; Montmorillonite K₁₀; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; pyridine; ethanol; water;
DOI:10.1016/0040-4039(94)88361-0