(R)-preclamol

Base Information

Chemical Name:(R)-preclamol
CAS No.:85976-54-1
Molecular Formula:C14H21 N O
Molecular Weight:219.327
Hs Code.:
UNII:8L7H229K4I
DSSTox Substance ID:DTXSID101017364
Nikkaji Number:J275.059G
Wikidata:Q27270713
Pharos Ligand ID:X7A566QUZB9D
ChEMBL ID:CHEMBL7393

Synonyms:(R)-preclamol;85976-54-1;Preclamol, (R)-;3-[(3R)-1-propylpiperidin-3-yl]phenol;R-3-PPP hydrochloride;CHEMBL7393;UNII-8L7H229K4I;8L7H229K4I;(R)-3-(1-Propylpiperidin-3-yl)phenol;R-3-(3-Hydroxyphenyl)-N-propylpiperidine HCl;R-3-(3-Hydroxyphenyl)-N-propylpiperidine hydrochloride;(+)-3-PPP;(R)-(+)-3-(3-Hydroxy-phenyl)-N-propylpiperidine;3-(1-Propyl-piperidin-3-yl)-phenol;(+)-Preclamol;(+)-3-(1-Propyl-piperidin-3-yl)-phenol;Lopac-P-102;Lopac-P-103;Lopac0_000986;cid_202478;SCHEMBL8354256;DTXSID101017364;R(+)-3-PPP;3PPP,(-);BDBM50010618;MFCD04113119;PDSP1_000628;PDSP2_000624;(R)-(+)-3-PPP;CCG-205066;SDCCGSBI-0050959.P002;NCGC00015776-01;NCGC00015776-02;NCGC00162308-02;NCGC00162308-04;MS-23215;3-((R)-1-Propyl-piperidin-3-yl)-phenol;HY-145454;(r)-3-(3-hydroxyphenyl)-N-propylpiperidine;CS-0374747;PHENOL, 3-((3R)-1-PROPYL-3-PIPERIDINYL)-;Q27270713;SR-01000075393-11;(R)-(+)-3-(3-HYDROXYPHENYL)-N-PROPYLPIPERIDINE

Suppliers and Price of (R)-preclamol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (R)-preclamol

Chemical Property:

Boiling Point:342.2°Cat760mmHg
Flash Point:158°C
PSA：23.47000
Density:g/cm³
LogP:2.91950
Solubility.:H2O: 150 mg/mL
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:219.162314293
Heavy Atom Count:16
Complexity:207

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCCN1CCCC(C1)C2=CC(=CC=C2)O
Isomeric SMILES:CCCN1CCC[C@@H](C1)C2=CC(=CC=C2)O

Technology Process of (R)-preclamol

There total 22 articles about (R)-preclamol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 91110-04-2
(3S)-(-)-3-(3-methoxyphenyl)-1-propylpiperidine

: 85976-54-1
(+)-preclamol

Guidance literature:: With hydrogen bromide; In water; at 120 ℃; for 2h; Inert atmosphere;
DOI:10.1039/c3cc45233f

Reference yield:

: 89874-51-1
(+)-(S)-3-(3-methoxyphenyl)-1-propylpiperidine

: 85966-89-8
preclamol

: 85976-54-1
(+)-preclamol

Guidance literature:: With hydrogen bromide; at 20 - 120 ℃; for 2h; Overall yield = 0.133 g; enantioselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1055/s-0037-1611759

Reference yield:

: (2R)-(-)-2-[3-(3-methoxyphenyl)piperidin-1-yl]-2-phenylethanol

: 85976-54-1
(+)-preclamol

Guidance literature:: Multi-step reaction with 4 steps

1: H₂, aq. HBF₄ / Pd/C / ethanol; ethyl acetate / 96 h / 232.7 Torr

2: Et₃N / toluene / 0.5 h / Ambient temperature

3: LiAlH₄ / tetrahydrofuran / 3 h / Heating

4: aq. HBr / 3 h / 120 °C

With lithium aluminium tetrahydride; tetrafluoroboric acid; hydrogen bromide; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate; toluene;
DOI:10.1021/jo961323+