91110-04-2

Upstream product

• 4373-67-5 3-(3-methoxyphenyl)pyridine 
• 79601-21-1 3-(3-methoxyphenylpiperidine) 
• 66107-33-3 3-methoxyphenyl triflate 
• 142-29-0 cyclopentene 
• 107-10-8 propylamine 
• 1461737-15-4 2-(3-methoxyphenyl)pentane-1,5-diol 
• 1461737-14-3 (S)-3-(m-anisyl)cyclopentene 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 626-55-1 3-Bromopyridine 
• 89920-96-7 N-benzyl-3(R)-(3-methoxyphenyl)piperidine hydrochloride 
• 89920-97-8 (R)-3-(3-methoxyphenyl)piperidine hydrochloride 
• 19725-18-9 (+)-3-(3-methoxyphenyl)piperidine hydrochloride 
• 103291-08-3 (3S)-(-)-3-(3-methoxyphenyl)piperidine 
• 450416-65-6 (3S,8R,8aR)-8-(3-methoxyphenyl)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 

Downstream Products

• 147161-64-6 (R)-N-propyl-3-(3-methoxy-4-aminophenyl)piperidine 
• 147161-62-4 (R)-N-propyl-3-(3-methoxy-4-nitrophenyl)piperidine 
• 85976-54-1 (+)-preclamol 

Relevant academic research and scientific papers

Highly active catalysts of bisphosphine oxides for asymmetric Heck reaction

Bisphosphine oxides formed highly active asymmetric Heck catalysts, which were applied in asymmetric synthesis of pharmacologically active azacycles. Olefin insertion proceeded via cis pathways, different from P,N-ligands.

Dynamic kinetic resolution of racemic γ-aryl-δ-oxoesters. Enantioselective synthesis of 3-arylpiperidines

Cyclodehydration of racemic γ-aryl-δ-oxoesters with (R)- or (S)-phenylglycinol stereoselectively affords bicyclic δ-lactams, in a process that involves a dynamic kinetic resolution. Subsequent reduction of these lactams leads to enantiopure 3-arylpiperidines. Starting from racemic aldehyde esters, this short sequence has been applied to the synthesis of (R)-3-phenylpiperidine and the antipsychotic drug (-)-3-PPP (an (S)-3-arylpiperidine), whereas starting from racemic ketone esters enantiopure cis-2-alkyl-3-arylpiperidines are prepared.

CHIRAL, POTENTIALLY IRREVERSIBLE LIGANDS FOR THE SIGMA RECEPTOR BASED ON THE STRUCTURE OF 3-(3-HYDROXYPHENYL)-N-PROPYLPIPERIDINE (3-PPP)

(+)-3-PPP is an optically active, highly potent and selective ligand for sigma receptors.The resolved enantiomeric pairs of potential irreversible sigma ligands (5a,b) and (9a,b) were designed and synthesized based on the structure of 3-PPP.An improved me

Resolved 3-(3-Hydroxyphenyl)-N-n-propylpiperidine and Its Analogues: Central Dopamine Receptor Activity

Seven enantiomeric pairs of N-alkyl analogues of 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP, 12) have been synthesized and evaluated pharmacologically (biochemistry and behavior) in order to examine their ability to interact with central dopamine (DA