(4R,6S)-4-{[(4-methoxyphenyl)methoxy]methyl}-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxane

Base Information

Chemical Name:(4R,6S)-4-{[(4-methoxyphenyl)methoxy]methyl}-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxane
CAS No.:1428899-24-4
Molecular Formula:C₃₀H₃₆O₅
Molecular Weight:476.613
Hs Code.:

Synonyms:(4R,6S)-4-{[(4-methoxyphenyl)methoxy]methyl}-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxane

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Chemical Property of (4R,6S)-4-{[(4-methoxyphenyl)methoxy]methyl}-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxane

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Technology Process of (4R,6S)-4-{[(4-methoxyphenyl)methoxy]methyl}-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxane

There total 10 articles about (4R,6S)-4-{[(4-methoxyphenyl)methoxy]methyl}-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1428899-23-3
(2R,4S)-1-[(4-methoxyphenyl)methoxy]-6-[4-(phenylmethoxy)phenyl]hexane-2,4-diol

: 77-76-9
2,2-dimethoxy-propane

: 1428899-24-4
(4R,6S)-4-{[(4-methoxyphenyl)methoxy]methyl}-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxane

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1002/hlca.201200165

Reference yield:

: 68486-77-1
3-(4-(benzyloxy)phenyl)propanal

: 1428899-24-4
(4R,6S)-4-{[(4-methoxyphenyl)methoxy]methyl}-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxane

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Reflux

3.1: titanium(IV) isopropylate; L-(+)-diisopropyl tartrate / dichloromethane / 0.5 h / -20 °C / Molecular sieve

3.2: 5 h / -20 °C

4.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 2 h / 0 - 20 °C / Inert atmosphere

5.1: toluene-4-sulfonic acid / dichloromethane / 0.5 h / 20 °C

With titanium(IV) isopropylate; lithium aluminium tetrahydride; n-butyllithium; L-(+)-diisopropyl tartrate; toluene-4-sulfonic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; hexane; dichloromethane; toluene; 3.1: |Sharpless Asymmetric Epoxidation / 3.2: |Sharpless Asymmetric Epoxidation;
DOI:10.1002/hlca.201200165

Reference yield:

: 1428899-16-4
6-[(4-methoxyphenyl)methoxy]-1-[4-(phenylmethoxy)phenyl]hex-4-yn-3-ol

: 1428899-24-4
(4R,6S)-4-{[(4-methoxyphenyl)methoxy]methyl}-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxane

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Reflux

2.1: titanium(IV) isopropylate; L-(+)-diisopropyl tartrate / dichloromethane / 0.5 h / -20 °C / Molecular sieve

2.2: 5 h / -20 °C

3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 2 h / 0 - 20 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / dichloromethane / 0.5 h / 20 °C

With titanium(IV) isopropylate; lithium aluminium tetrahydride; L-(+)-diisopropyl tartrate; toluene-4-sulfonic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane; toluene; 2.1: |Sharpless Asymmetric Epoxidation / 2.2: |Sharpless Asymmetric Epoxidation;
DOI:10.1002/hlca.201200165