diphenyl(2‐phenyl‐1,2,3,4‐tetrahydroisoquinolin‐1‐yl)phosphine oxide

Base Information

• Chemical Name: diphenyl(2‐phenyl‐1,2,3,4‐tetrahydroisoquinolin‐1‐yl)phosphine oxide
• CAS No.: 1382465-02-2
• Molecular Formula: C₂₇H₂₄NOP
• Molecular Weight: 409.467
• Mol file: 1382465-02-2.mol

Synonyms:diphenyl(2‐phenyl‐1,2,3,4‐tetrahydroisoquinolin‐1‐yl)phosphine oxide

Chemical Property of diphenyl(2‐phenyl‐1,2,3,4‐tetrahydroisoquinolin‐1‐yl)phosphine oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of diphenyl(2‐phenyl‐1,2,3,4‐tetrahydroisoquinolin‐1‐yl)phosphine oxide

There total 4 articles about diphenyl(2‐phenyl‐1,2,3,4‐tetrahydroisoquinolin‐1‐yl)phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-phenyl-1,2,3,4-tetrahydroisoquinoline (3340-78-1) + diphenylphosphane (829-85-6) → diphenyl(2‐phenyl‐1,2,3,4‐tetrahydroisoquinolin‐1‐yl)phosphine oxide (1382465-02-2)

Guidance literature:

With oxygen; tris(p-bromophenylammoniumyl) hexachloroantimonate; In tetrahydrofuran; at 20 ℃;

DOI:10.1039/c3ob42454e

Reference yield: 92.0%

2-phenyl-1,2,3,4-tetrahydroisoquinoline (3340-78-1) + Diphenylphosphine oxide (4559-70-0) → diphenyl(2‐phenyl‐1,2,3,4‐tetrahydroisoquinolin‐1‐yl)phosphine oxide (1382465-02-2)

Guidance literature:

With polymer-immobilized Ir(vppy)2(dtbppy)PF₆; air; In methanol; at 20 ℃; for 14h; under 760.051 Torr; Irradiation;

DOI:10.1039/c4gc00058g

Reference yield:

1,2,3,4-tetrahydroisoquinoline (91-21-4) → diphenyl(2‐phenyl‐1,2,3,4‐tetrahydroisoquinolin‐1‐yl)phosphine oxide (1382465-02-2)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; potassium dihydrogenphosphate / isopropyl alcohol; ethylene glycol / 24 h / 85 - 90 °C / Schlenk technique; Inert atmosphere

2: cobalt(II) acetate hydrate; N-hydroxyphthalimide / acetonitrile / 16 h / 80 °C

With potassium dihydrogenphosphate; copper(l) iodide; N-hydroxyphthalimide; cobalt(II) acetate hydrate; In ethylene glycol; isopropyl alcohol; acetonitrile;

DOI:10.1021/acs.joc.8b00674

upstream raw materials:

2-phenyl-1,2,3,4-tetrahydroisoquinoline

Diphenylphosphine oxide

diphenylphosphane

1,2,3,4-tetrahydroisoquinoline

Downstream raw materials:

2-phenyl-3,4-dihydroisoquinolin-1(2H)-one

2-phenylisoquinolin-1(2H)-one