5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-imine p-toluenesulfonic acid

Base Information

• Chemical Name: 5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-imine p-toluenesulfonic acid
• CAS No.: 959749-10-1
• Molecular Formula: C₇H₈O₃S*C₁₂H₂₀N₂OS
• Molecular Weight: 412.574

Synonyms:5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-imine p-toluenesulfonic acid

Chemical Property of 5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-imine p-toluenesulfonic acid

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Technology Process of 5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-imine p-toluenesulfonic acid

There total 1 articles about 5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-imine p-toluenesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-tert-butyl-1,3-thiazol-2-amine (299417-31-5) + [(2R)-tetrahydrofuran-2-yl]methyl 4-methylbenzenesulfonate (22415-60-7,34583-63-6,114114-90-8) → 5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-imine p-toluenesulfonic acid (959749-10-1)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 90 ℃; for 72h;

Reference yield: 40.0%

2-fluoro-5-(trifluoromethyl)benzoyl chloride (207981-46-2) + 5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-imine p-toluenesulfonic acid (959749-10-1) → N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-fluoro-5-(trifluoromethyl)benzamide (1065640-04-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 50 ℃; for 4h;

Reference yield:

5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-imine p-toluenesulfonic acid (959749-10-1) + 2-methoxy-5-chlorobenzoyl chloride (29568-33-0) → N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide (959749-08-7)

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; at 60 ℃; for 16h;

upstream raw materials:

5-tert-butyl-1,3-thiazol-2-amine

[(2R)-tetrahydrofuran-2-yl]methyl 4-methylbenzenesulfonate

Downstream raw materials:

N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide

N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-fluoro-5-(trifluoromethyl)benzamide

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