N-(2-chloro-5-(isoquinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

Base Information

• Chemical Name: N-(2-chloro-5-(isoquinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide
• CAS No.: 1201842-41-2
• Molecular Formula: C₂₀H₁₃ClFN₃O₂S
• Molecular Weight: 413.86
• Mol file: 1201842-41-2.mol

Synonyms:N-(2-chloro-5-(isoquinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

Chemical Property of N-(2-chloro-5-(isoquinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-chloro-5-(isoquinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

There total 5 articles about N-(2-chloro-5-(isoquinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.4%

6-bromo-isoquinoline (34784-05-9) + N-(2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide (1112983-31-9) → N-(2-chloro-5-(isoquinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide (1201842-41-2)

Guidance literature:

DOI:10.1021/jm200386s

Reference yield:

3-amino-5-bromo-2-chloropyridine (588729-99-1) → N-(2-chloro-5-(isoquinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide (1201842-41-2)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 100 °C / Inert atmosphere

2: water; sodium carbonate / methanol / 20 h / 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 120 °C / Inert atmosphere

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; potassium acetate; sodium carbonate; In 1,4-dioxane; methanol; 4: Suzuki coupling;

DOI:10.1021/jm200386s

Reference yield:

N-(5-bromo-2-chloro-pyridine-3-yl)-4-fluorobenzenesulfonamide (887309-87-7) → N-(2-chloro-5-(isoquinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide (1201842-41-2)

Guidance literature:

Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 120 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; 2: Suzuki coupling;

DOI:10.1021/jm200386s

upstream raw materials:

6-bromo-isoquinoline

N-(2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

3-amino-5-bromo-2-chloropyridine

N-(5-bromo-2-chloro-pyridine-3-yl)-4-fluorobenzenesulfonamide