ethyl 2-(N-ethoxycarbonyl-N-pivaloylamino)-3-fluoro-6-methoxymethoxybenzoate

Base Information

Chemical Name:ethyl 2-(N-ethoxycarbonyl-N-pivaloylamino)-3-fluoro-6-methoxymethoxybenzoate
CAS No.:152836-26-5
Molecular Formula:C₁₉H₂₆FNO₇
Molecular Weight:399.416
Hs Code.:

Synonyms:ethyl 2-(N-ethoxycarbonyl-N-pivaloylamino)-3-fluoro-6-methoxymethoxybenzoate

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Chemical Property of ethyl 2-(N-ethoxycarbonyl-N-pivaloylamino)-3-fluoro-6-methoxymethoxybenzoate

Chemical Property:

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Technology Process of ethyl 2-(N-ethoxycarbonyl-N-pivaloylamino)-3-fluoro-6-methoxymethoxybenzoate

There total 4 articles about ethyl 2-(N-ethoxycarbonyl-N-pivaloylamino)-3-fluoro-6-methoxymethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3282-30-2
pivaloyl chloride

: 152169-38-5
ethyl 2-(N-ethoxycarbonylamino)-3-fluoro-6-methoxymethoxybenzoate

: 152836-26-5
ethyl 2-(N-ethoxycarbonyl-N-pivaloylamino)-3-fluoro-6-methoxymethoxybenzoate

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 ℃; for 1.5h; Yield given;
DOI:10.1021/jm9700326

Reference yield:

: 146463-87-8
ethyl 2-(N-ethoxycarbonyl-N-pivaloyl)amino-6-(tetrahydropyran-2-yloxy)benzoate

: 152836-26-5
ethyl 2-(N-ethoxycarbonyl-N-pivaloylamino)-3-fluoro-6-methoxymethoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / conc. aq. HCl / ethanol / 3.5 h / Heating

2: 42 percent / N-fluoro-3,5-dichloropyridinium triflate / CH₂Cl₂ / 22 h / Heating

3: EtN(i-Pr)2 / CH₂Cl₂ / 0.33 h / 0 °C

4: NaH / tetrahydrofuran / 1.5 h / 0 °C

With hydrogenchloride; sodium hydride; 1-fluoro-3,5-dichloropyridinium trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm9700326

Reference yield:

: 152169-36-3
ethyl 6-(N-ethoxycarbonylamino)-2-hydroxybenzoate

: 152836-26-5
ethyl 2-(N-ethoxycarbonyl-N-pivaloylamino)-3-fluoro-6-methoxymethoxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 42 percent / N-fluoro-3,5-dichloropyridinium triflate / CH₂Cl₂ / 22 h / Heating

2: EtN(i-Pr)2 / CH₂Cl₂ / 0.33 h / 0 °C

3: NaH / tetrahydrofuran / 1.5 h / 0 °C

With sodium hydride; 1-fluoro-3,5-dichloropyridinium trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm9700326