5-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylpentanoic acid

Base Information

Chemical Name:5-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylpentanoic acid
CAS No.:868836-03-7
Molecular Formula:C₂₄H₃₉N₃O₅
Molecular Weight:449.591
Hs Code.:

Synonyms:5-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylpentanoic acid

Suppliers and Price of 5-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylpentanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylpentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylpentanoic acid

There total 4 articles about 5-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.8%

: 868835-98-7
5-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylpentanoic acid methyl ester

: 868836-03-7
5-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylpentanoic acid

Guidance literature:: 5-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylpentanoic acid methyl ester; With lithium hydroxide; water; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

With hydrogenchloride; In tetrahydrofuran; water; at 0 ℃;

Reference yield:

: 868835-94-3
1-N-{4-[(N,N-dimethyl)amino]benzyl}-1-N-[(tert-butyloxy)carbonyl]-4-aminobutylamine

: 868836-03-7
5-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylpentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 80.2 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

2: aq. LiOH / tetrahydrofuran / 0 - 20 °C

With lithium hydroxide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0505009

Reference yield:

: 868835-87-4
N-{4-[(N,N-dimethylamino)benzyl]butyl}phthalimide

: 868836-03-7
5-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylpentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaHCO₃; NaCl / CH₂Cl₂ / 12 h / Heating

2: 88.3 percent / hydrazine / methanol / 12 h / Heating

3: 80.2 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

4: aq. LiOH / tetrahydrofuran / 0 - 20 °C

With lithium hydroxide; sodium hydrogencarbonate; triethylamine; sodium chloride; hydrazine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm0505009