ethyl 4-((bis(benzyloxy)phosphoryl)oxy)-5-(dimethylcarbamoyl)-3-hydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

Base Information

Chemical Name:ethyl 4-((bis(benzyloxy)phosphoryl)oxy)-5-(dimethylcarbamoyl)-3-hydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate
CAS No.:1443054-07-6
Molecular Formula:C₃₁H₃₃N₂O₉P
Molecular Weight:608.585
Hs Code.:

Synonyms:ethyl 4-((bis(benzyloxy)phosphoryl)oxy)-5-(dimethylcarbamoyl)-3-hydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

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Chemical Property of ethyl 4-((bis(benzyloxy)phosphoryl)oxy)-5-(dimethylcarbamoyl)-3-hydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

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Technology Process of ethyl 4-((bis(benzyloxy)phosphoryl)oxy)-5-(dimethylcarbamoyl)-3-hydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

There total 11 articles about ethyl 4-((bis(benzyloxy)phosphoryl)oxy)-5-(dimethylcarbamoyl)-3-hydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 17176-77-1
Dibenzyl phosphite

: 1443052-79-6
ethyl 5-(dimethylcarbamoyl)-3,4-dihydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

: 1443054-07-6
ethyl 4-((bis(benzyloxy)phosphoryl)oxy)-5-(dimethylcarbamoyl)-3-hydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

Guidance literature:: ethyl 5-(dimethylcarbamoyl)-3,4-dihydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate; With dmap; carbon tetrabromide; N-ethyl-N,N-diisopropylamine; In acetonitrile; at -10 ℃; for 0.5h;

Dibenzyl phosphite; In acetonitrile; at 0 ℃; for 1h;

Reference yield:

: 104-94-9
4-methoxy-aniline

: 1443054-07-6
ethyl 4-((bis(benzyloxy)phosphoryl)oxy)-5-(dimethylcarbamoyl)-3-hydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium acetate; sodium iodide / perchloric acid / 3 h / 90 °C

2.1: sodium hydroxide; water / tetrahydrofuran; ethanol / 3 h / 40 °C

2.2: pH 3

3.1: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 1 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 60 °C

5.1: sodium ethanolate / ethanol / 1.5 h / 85 °C

6.1: N-ethyl-N,N-diisopropylamine; dmap; carbon tetrabromide / acetonitrile / 0.5 h / -10 °C

6.2: 1 h / 0 °C

With dmap; carbon tetrabromide; water; sodium ethanolate; sodium acetate; N-ethyl-N,N-diisopropylamine; HATU; sodium iodide; sodium hydroxide; In tetrahydrofuran; perchloric acid; ethanol; acetonitrile;

Reference yield:

: 98269-30-8
diethyl 2,2’-((4-methoxyphenyl)azanediyl)diacetate

: 1443054-07-6
ethyl 4-((bis(benzyloxy)phosphoryl)oxy)-5-(dimethylcarbamoyl)-3-hydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium ethanolate / ethanol / 1 h / 100 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

3.1: sodium hydroxide; water / tetrahydrofuran; ethanol / 16 h / 50 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

5.1: palladium 10% on activated carbon; hydrogen / ethanol / 1.5 h / 20 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine; dmap; carbon tetrabromide / acetonitrile / 0.5 h / -10 °C

6.2: 1 h / 0 °C

With dmap; carbon tetrabromide; palladium 10% on activated carbon; water; hydrogen; sodium ethanolate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;