1-(4-{2-[(4-methoxyphenyl)thio]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutanamine

Base Information

Chemical Name:1-(4-{2-[(4-methoxyphenyl)thio]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutanamine
CAS No.:1374261-32-1
Molecular Formula:C₃₁H₂₇N₅OS
Molecular Weight:517.654
Hs Code.:

Synonyms:1-(4-{2-[(4-methoxyphenyl)thio]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutanamine

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Chemical Property of 1-(4-{2-[(4-methoxyphenyl)thio]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutanamine

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Technology Process of 1-(4-{2-[(4-methoxyphenyl)thio]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutanamine

There total 7 articles about 1-(4-{2-[(4-methoxyphenyl)thio]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 696-63-9
4-Methoxybenzenethiol

: 1374260-87-3
tert-butyl {1-[4-(2-bromo-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

: 1374261-32-1
1-(4-{2-[(4-methoxyphenyl)thio]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutanamine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl-formamide; at 160 ℃; for 1h;

Reference yield:

: 1374260-84-0
tert-butyl {1-[4-(9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

: 1374261-32-1
1-(4-{2-[(4-methoxyphenyl)thio]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutanamine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium perbromide hydrobromide / tetrahydrofuran / -78 - 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide / 1 h / 160 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; pyridinium perbromide hydrobromide; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 885-70-1
5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one

: 1374261-32-1
1-(4-{2-[(4-methoxyphenyl)thio]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutanamine

Guidance literature:: Multi-step reaction with 7 steps

1: Lawessons reagent; pyridine / 18 h / 100 °C

2: 1 h / 95 °C

3: acetic acid / 13 h / 105 °C

4: N-Bromosuccinimide / tetrahydrofuran / 2 h / 0 - 20 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 15 h / Reflux

6: pyridinium perbromide hydrobromide / tetrahydrofuran / -78 - 20 °C

7: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide / 1 h / 160 °C

With Lawessons reagent; pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; pyridinium perbromide hydrobromide; sodium hydrogencarbonate; potassium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene;