2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)-N-methoxy-N-methylacetamide

Base Information

Chemical Name:2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)-N-methoxy-N-methylacetamide
CAS No.:953786-54-4
Molecular Formula:C₁₉H₂₂INO₅
Molecular Weight:471.292
Hs Code.:

Synonyms:2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)-N-methoxy-N-methylacetamide

Suppliers and Price of 2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)-N-methoxy-N-methylacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)-N-methoxy-N-methylacetamide

Chemical Property:

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Technology Process of 2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)-N-methoxy-N-methylacetamide

There total 5 articles about 2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)-N-methoxy-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₁₇O₅I

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 953786-54-4
2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)-N-methoxy-N-methylacetamide

Guidance literature:: C₁₇H₁₇O₅I; With pivaloyl chloride; triethylamine; In dichloromethane; at 0 ℃;

N,O-dimethylhydroxylamine*hydrochloride; With triethylamine; In dichloromethane; at 0 ℃; for 2h; Further stages.;
DOI:10.1021/ol701757f

Reference yield:

: C₂₂H₂₅IO₆

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 953786-54-4
2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)-N-methoxy-N-methylacetamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1021/jo902006q

Reference yield:

: 909766-98-9
4-benzyloxy-6-iodo-2,3-dimethoxybenzaldehyde

: 953786-54-4
2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)-N-methoxy-N-methylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: KOt-Bu / tetrahydrofuran / 0 - 20 °C

1.2: tetrahydrofuran / 16 h / 20 °C

2.1: 423 mg / aq. HCl / acetone / 12 h / Heating

3.1: 2-methyl-2-butene; NaH₂PO₄; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 20 °C

4.1: triethylamine; pivaloyl chloride / CH₂Cl₂ / 0 °C

4.2: 31.8 mg / triethylamine / CH₂Cl₂ / 2 h / 0 °C

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; potassium tert-butylate; pivaloyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; water; acetone; tert-butyl alcohol; 1.2: Wittig reaction;
DOI:10.1021/ol701757f