2-(trideuteriophenyl)pyridine

Base Information

• Chemical Name: 2-(trideuteriophenyl)pyridine
• CAS No.: 1261287-94-8
• Molecular Formula: C₁₁H₉N
• Molecular Weight: 158.175
• Mol file: 1261287-94-8.mol

Synonyms:2-(trideuteriophenyl)pyridine

Chemical Property of 2-(trideuteriophenyl)pyridine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(trideuteriophenyl)pyridine

There total 3 articles about 2-(trideuteriophenyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(phenyl-d5)pyridine (105664-48-0) → 2-(trideuteriophenyl)pyridine (1261287-94-8)

Guidance literature:

With dodecacarbonyl-triangulo-triruthenium; oxone||potassium monopersulfate triple salt; tetrabutylammonium acetate; silver trifluoroacetate; In 1,2-dichloro-ethane; at 95 ℃; for 36h; Sealed tube;

DOI:10.1021/jacs.6b03402

Reference yield:

2-bromo-pyridine (109-04-6) + bromobenzene-d5 (4165-57-5) → 2-(trideuteriophenyl)pyridine (1261287-94-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: magnesium; ethylene dibromide / tetrahydrofuran / 3.5 h / Inert atmosphere; Reflux

1.2: 0.5 h / 20 °C

1.3: 12 h / -40 - 20 °C

2.1: [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; potassium carbonate; mesitylenecarboxylic acid; water / N,N-dimethyl acetamide / 5 h / 100 °C / Microwave irradiation

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; mesitylenecarboxylic acid; water; potassium carbonate; magnesium; ethylene dibromide; In tetrahydrofuran; N,N-dimethyl acetamide;

DOI:10.1002/anie.201507100

Reference yield:

silver tetrafluoroborate (14104-20-2) + 2-(phenyl-d5)pyridine (105664-48-0) + diphenyl acetylene (501-65-5) → 2-(trideuteriophenyl)pyridine (1261287-94-8) + C25H14(2)H4N(1+)*BF4(1-)

Guidance literature:

With carbonyl(pentamethylcyclopentadienyl)cobalt diiodide; water; copper diacetate; at 100 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/adsc.201600194

upstream raw materials:

2-(phenyl-d5)pyridine

2-bromo-pyridine

bromobenzene-d5

silver tetrafluoroborate