methyl (15α,17β)-3-(benzyloxy)-17-methoxyestra-1,3,5(10)-triene-15-carboxylate

Base Information

Chemical Name:methyl (15α,17β)-3-(benzyloxy)-17-methoxyestra-1,3,5(10)-triene-15-carboxylate
CAS No.:1424348-13-9
Molecular Formula:C₂₈H₃₄O₄
Molecular Weight:434.576
Hs Code.:

Synonyms:methyl (15α,17β)-3-(benzyloxy)-17-methoxyestra-1,3,5(10)-triene-15-carboxylate

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Chemical Property of methyl (15α,17β)-3-(benzyloxy)-17-methoxyestra-1,3,5(10)-triene-15-carboxylate

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Technology Process of methyl (15α,17β)-3-(benzyloxy)-17-methoxyestra-1,3,5(10)-triene-15-carboxylate

There total 2 articles about methyl (15α,17β)-3-(benzyloxy)-17-methoxyestra-1,3,5(10)-triene-15-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 534572-70-8
(15α,17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-15-carboxylic acid

: 74-88-4
methyl iodide

: 1424348-13-9
methyl (15α,17β)-3-(benzyloxy)-17-methoxyestra-1,3,5(10)-triene-15-carboxylate

Guidance literature:: (15α,17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-15-carboxylic acid; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 17 - 20 ℃; for 1.5h;

Reference yield:

: 138743-03-0
(14α)-3-benzyloxy-1,3,5(10),15-estratetraen-17-one

: 1424348-13-9
methyl (15α,17β)-3-(benzyloxy)-17-methoxyestra-1,3,5(10)-triene-15-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / dimethyl sulfoxide / 40 °C

2: sodium nitrite; acetic acid / N,N-dimethyl-formamide

3: sodium tetrahydroborate

4: N,N-dimethyl-formamide

With sodium tetrahydroborate; potassium carbonate; acetic acid; sodium nitrite; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2019.126643

Reference yield: 88.0%

: 1424348-13-9
methyl (15α,17β)-3-(benzyloxy)-17-methoxyestra-1,3,5(10)-triene-15-carboxylate

: 1424348-11-7
(15α,17β)-3-(benzyloxy)-17-methoxyestra-1,3,5(10)-triene-15-carboxylic acid

Guidance literature:: methyl (15α,17β)-3-(benzyloxy)-17-methoxyestra-1,3,5(10)-triene-15-carboxylate; With water; potassium hydroxide; In ethanol; for 7h; Reflux;

With hydrogenchloride; In water;