Technology Process of (7'R,8R,8'R)-4,4'-bis(tert-butyldimethylsilanyloxy)-7'-hydroxy-3,3'-dimethoxylignano-9,9'-lactone
There total 15 articles about (7'R,8R,8'R)-4,4'-bis(tert-butyldimethylsilanyloxy)-7'-hydroxy-3,3'-dimethoxylignano-9,9'-lactone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(7'S,8R,8'R)-4,4'-bis(tert-butyldimethylsilanyloxy)-7'-hydroxy-3,3'-dimethoxylignano-9,9'-lactone;
With
triphenylphosphine; diisopropyl diazenedicarboxylate; 4-nitro-benzoic acid;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
With
potassium carbonate;
In
methanol; water;
at 20 ℃;
for 1h;
DOI:10.3390/molecules26195838
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 92 percent / MgBr2 / diethyl ether / 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
2.2: 88 percent / 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran; hexane / 2 h / -78 °C
3.1: 71 percent / NaBH4; KOH / ethanol / 3 h / 0 - 20 °C
4.1: LDA / tetrahydrofuran / 2 h / -78 °C
4.2: 68 percent / N,N-dimethyl-2-imidazolidinone / tetrahydrofuran / -78 - 20 °C
5.1: 55 percent / (CF3CO2)2IPh; H2O / acetonitrile / 0.5 h / 20 °C
6.1: L-Selectride(R) / tetrahydrofuran / 2 h / -78 °C
With
potassium hydroxide; sodium tetrahydroborate; n-butyllithium; water; L-Selectride; bis-[(trifluoroacetoxy)iodo]benzene; magnesium bromide; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; ethanol; hexane; acetonitrile;
2.2: Michael addition;
DOI:10.1039/b513303c
- Guidance literature:
-
With
potassium carbonate;
In
methanol; water;
for 0.5h;
DOI:10.1021/ol049878b
